Aim: To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis. Methods: A comprehensive literature search was conducted. Studies were selected according to PICO: Participants: children aged 0-12 years with acute diarrhea; Intervention: GT; Comparison: oral rehydration solution and/or placebo; Outcomes: diarrhea-related outcomes. Results: Three published randomized controlled trials were identified of pediatric diarrhea treated with GT (n = 203) or control (n = 204). GT significantly (p < 0.01) reduced stool frequency at 12 h in two randomized controlled trials. A significant treatment effect (risk ratio = 0.74; p < 0.01) in favor of GT was found for the exploratory composite outcome of 'diarrhea or liquid stools at 24 h' in three studies. Risk ratios in a single study which reported the percentage of patients with liquid stools at 12, 24 and 48 h favored GT at all time points. No significant differences were found between GT and control for patients with diarrhea at 12 or 24 h or for duration of diarrhea. Conclusion: GT improved stool frequency and stool consistency in children with acute diarrhea, although further well-controlled studies would be useful to confirm a beneficial treatment effect.

Efficacy of gelatin tannate for acute diarrhea in children: A systematic review and meta-analysis / Aloi, M.; Mennini, M.. - In: JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH. - ISSN 2042-6305. - 8:2(2019), pp. 91-102. [10.2217/cer-2018-0115]

Efficacy of gelatin tannate for acute diarrhea in children: A systematic review and meta-analysis

Aloi M.;Mennini M.
2019

Abstract

Aim: To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis. Methods: A comprehensive literature search was conducted. Studies were selected according to PICO: Participants: children aged 0-12 years with acute diarrhea; Intervention: GT; Comparison: oral rehydration solution and/or placebo; Outcomes: diarrhea-related outcomes. Results: Three published randomized controlled trials were identified of pediatric diarrhea treated with GT (n = 203) or control (n = 204). GT significantly (p < 0.01) reduced stool frequency at 12 h in two randomized controlled trials. A significant treatment effect (risk ratio = 0.74; p < 0.01) in favor of GT was found for the exploratory composite outcome of 'diarrhea or liquid stools at 24 h' in three studies. Risk ratios in a single study which reported the percentage of patients with liquid stools at 12, 24 and 48 h favored GT at all time points. No significant differences were found between GT and control for patients with diarrhea at 12 or 24 h or for duration of diarrhea. Conclusion: GT improved stool frequency and stool consistency in children with acute diarrhea, although further well-controlled studies would be useful to confirm a beneficial treatment effect.
2019
diarrhea; gelatin tannate; meta-analysis; pediatrics
01 Pubblicazione su rivista::01a Articolo in rivista
Efficacy of gelatin tannate for acute diarrhea in children: A systematic review and meta-analysis / Aloi, M.; Mennini, M.. - In: JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH. - ISSN 2042-6305. - 8:2(2019), pp. 91-102. [10.2217/cer-2018-0115]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1314458
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