Historically, analysis of intragastric exfoliative cytology (IEC) of gastric cancer (GC) was used with diagnostic intent only. With the successful advent of endoscopic biopsy, the rate of detection of GC has improved worldwide and, as a consequence, IEC has been progressively abandoned. Today, however, there is a renewed interest in this field of research as witnessed by several pertinent publications. As discussed in this review, in fact, currently the importance of analyzing IEC in patients with early and advanced GC seems to reside in its clinicopathological and prognostic significance. In fact, compared with non-sloughing tumors, GC exhibiting intragastric exfoliation was recently associated with aggressive tumor phenotype (characterized by deeper infiltration of the gastric wall, lymph nodal or distant metastases, angiolymphatic and perineural invasion) and poorer prognosis. Adoption of IEC examination in routine practice might help identify patients at higher risk of developing local recurrence and peritoneal metastasis from early and advanced GC, optimizing their treatment and improving quality of life and life expectancy.

Advances in intraluminal exfoliative cytology of gastric cancer. oncologic implication of the sixth metastatic route (Metastasis VI) / Virgilio, Edoardo; Giarnieri, Enrico; Montagnini, Monica; Villani, Sandra; Giovagnoli, Maria Rosaria; Mercantini, Paolo; Balducci, Genoveffa; Cavallini, Marco. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 39:8(2019), pp. 4019-4022. [10.21873/anticanres.13557]

Advances in intraluminal exfoliative cytology of gastric cancer. oncologic implication of the sixth metastatic route (Metastasis VI)

Virgilio, Edoardo
Primo
;
Giarnieri, Enrico
Secondo
;
Montagnini, Monica;Villani, Sandra;Giovagnoli, Maria Rosaria;Mercantini, Paolo;Balducci, Genoveffa;Cavallini, Marco
Ultimo
2019

Abstract

Historically, analysis of intragastric exfoliative cytology (IEC) of gastric cancer (GC) was used with diagnostic intent only. With the successful advent of endoscopic biopsy, the rate of detection of GC has improved worldwide and, as a consequence, IEC has been progressively abandoned. Today, however, there is a renewed interest in this field of research as witnessed by several pertinent publications. As discussed in this review, in fact, currently the importance of analyzing IEC in patients with early and advanced GC seems to reside in its clinicopathological and prognostic significance. In fact, compared with non-sloughing tumors, GC exhibiting intragastric exfoliation was recently associated with aggressive tumor phenotype (characterized by deeper infiltration of the gastric wall, lymph nodal or distant metastases, angiolymphatic and perineural invasion) and poorer prognosis. Adoption of IEC examination in routine practice might help identify patients at higher risk of developing local recurrence and peritoneal metastasis from early and advanced GC, optimizing their treatment and improving quality of life and life expectancy.
gastric cancer; gastric cytology; gastric lavage; GL; intragastric exfoliation; Metastasis VI; peritoneal seeding; ESD; review
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Advances in intraluminal exfoliative cytology of gastric cancer. oncologic implication of the sixth metastatic route (Metastasis VI) / Virgilio, Edoardo; Giarnieri, Enrico; Montagnini, Monica; Villani, Sandra; Giovagnoli, Maria Rosaria; Mercantini, Paolo; Balducci, Genoveffa; Cavallini, Marco. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 39:8(2019), pp. 4019-4022. [10.21873/anticanres.13557]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1313561
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