Type 2 diabetes is a complex, heterogeneous group of metabolic disorders that has reached epidemic proportions, affecting over 5% of the population in western countries. The pathophysiology of type 2 diabetes includes two apparently distinct defects, ie impairments in insulin action at the level of skeletal muscle, fat and liver, and a failure in insulin secretory capacity of pancreatic beta-cells. There is strong evidence that genetic factors play an important role in both of these components given the familial nature, the high concordance rate between monozygotic twins, and the high prevalence in certain ethnic groups.
Searching for type 2 diabetes genes. prospects in pharmacotherapy / Sesti, G. - In: PHARMACOGENOMICS JOURNAL. - ISSN 1470-269X. - 2:1(2002), pp. 25-29. [10.1038/sj/tpj/6500078]
Searching for type 2 diabetes genes. prospects in pharmacotherapy
SESTI G
Primo
Writing – Original Draft Preparation
2002
Abstract
Type 2 diabetes is a complex, heterogeneous group of metabolic disorders that has reached epidemic proportions, affecting over 5% of the population in western countries. The pathophysiology of type 2 diabetes includes two apparently distinct defects, ie impairments in insulin action at the level of skeletal muscle, fat and liver, and a failure in insulin secretory capacity of pancreatic beta-cells. There is strong evidence that genetic factors play an important role in both of these components given the familial nature, the high concordance rate between monozygotic twins, and the high prevalence in certain ethnic groups.File | Dimensione | Formato | |
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