Abstract Background and aims: A link between increased blood viscosity and type 2 diabetes has been previously reported. Herein, we investigated the association of blood viscosity with prediabetes, identified by glycated hemoglobin A1c (HbA1c) according to the new American Diabetes Association criteria, and subclinical atherosclerosis. Methods and results: The study cohort includes 1136 non-diabetic adults submitted to anthropometrical evaluation, an oral glucose tolerance test and ultrasound measurement of carotid intima-media thickness (IMT). Whole blood viscosity was estimated using a validated formula based on hematocrit and total plasma proteins. After adjusting for age, and gender, individuals with HbA1c-defined prediabetes (HbA1c 5.7e6.4% [39e47 mmol/mol]) exhibited significantly higher values of hematocrit, and predicted blood viscosity as comparedwith controls. Increased levels of IMTwere observed in subjectswithHbA1c-defined prediabetes in comparison to controls. Predicted blood viscosity was positively correlated with age, waist circumference, blood pressure, cholesterol, triglycerides, fibrinogen, white blood cell, HbA1c, fasting and 2-h post-load glucose levels, fasting insulin, IMT and inversely correlated with HDL and Matsuda index of insulin sensitivity. Of the three glycemic parameters, i.e. HbA1c, fasting and 2- h post-load glucose, only HbA1c showed a significant correlation with predicted blood viscosity (bZ0.054, PZ0.04) in a multivariate regression analysis model including multiple atherosclerosis risk factors. Conclusion: The study shows that individuals with HbA1c-defined prediabetes have increased predicted blood viscosity and IMT. The HbA1c criterion may be helpful to capture individuals with an increased risk of diabetes and cardiovascular disease who may benefit from an intensive lifestyle intervention.

Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels / Marini, Ma; Fiorentino, Tv; Andreozzi, F; Mannino, Gc; Succurro, E; Sciacqua, A; Perticone, F; Sesti, G. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 27:(2017), pp. 601-608. [10.1016/j.numecd.2017.04.001]

Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels

Sesti G
Ultimo
Writing – Original Draft Preparation
2017

Abstract

Abstract Background and aims: A link between increased blood viscosity and type 2 diabetes has been previously reported. Herein, we investigated the association of blood viscosity with prediabetes, identified by glycated hemoglobin A1c (HbA1c) according to the new American Diabetes Association criteria, and subclinical atherosclerosis. Methods and results: The study cohort includes 1136 non-diabetic adults submitted to anthropometrical evaluation, an oral glucose tolerance test and ultrasound measurement of carotid intima-media thickness (IMT). Whole blood viscosity was estimated using a validated formula based on hematocrit and total plasma proteins. After adjusting for age, and gender, individuals with HbA1c-defined prediabetes (HbA1c 5.7e6.4% [39e47 mmol/mol]) exhibited significantly higher values of hematocrit, and predicted blood viscosity as comparedwith controls. Increased levels of IMTwere observed in subjectswithHbA1c-defined prediabetes in comparison to controls. Predicted blood viscosity was positively correlated with age, waist circumference, blood pressure, cholesterol, triglycerides, fibrinogen, white blood cell, HbA1c, fasting and 2-h post-load glucose levels, fasting insulin, IMT and inversely correlated with HDL and Matsuda index of insulin sensitivity. Of the three glycemic parameters, i.e. HbA1c, fasting and 2- h post-load glucose, only HbA1c showed a significant correlation with predicted blood viscosity (bZ0.054, PZ0.04) in a multivariate regression analysis model including multiple atherosclerosis risk factors. Conclusion: The study shows that individuals with HbA1c-defined prediabetes have increased predicted blood viscosity and IMT. The HbA1c criterion may be helpful to capture individuals with an increased risk of diabetes and cardiovascular disease who may benefit from an intensive lifestyle intervention.
2017
blood viscosity; HbA1c; prediabetes
01 Pubblicazione su rivista::01a Articolo in rivista
Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels / Marini, Ma; Fiorentino, Tv; Andreozzi, F; Mannino, Gc; Succurro, E; Sciacqua, A; Perticone, F; Sesti, G. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 27:(2017), pp. 601-608. [10.1016/j.numecd.2017.04.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1312216
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