Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are two dysglycemic disorders that have been referred to as categories of increased risk for type 2 diabetes (T2DM) as well as for cardiovascular disease [1]. Recently, the American Diabetes Association (ADA) has proposed a glycated hemoglobin (HbA1c) value of 5.7–6.4% (39–46 mmol/mol) as a new indicator of prediabetes in addition to IFG and IGT [2]. The three glycemic parameters used as measures of dysglycemia, i.e. fasting plasma glucose (FPG), 2-h post-challenge glucose (2-h PG), and HbA1c reflect different features of glucose metabolism with FPG reflecting steady-state glucose metabolism, 2-h PG being an indicator of glycemic response to meal, and HbA1c, an indicator of average blood glucose concentrations over 2–3 months, capturing both fasting and post-meal glycemia. There is evidence that FPG and 2-h PG in the range diagnostic for IFG and IGT have an impact on cardiac geometry and function and are associated with left ventricular hypertrophy (LVH), a well-established predictor of cardiovascular morbidity and mortality.
Characterization of left ventricular mass in individuals at risk for type 2 diabetes identified by HbA1c levels according to the American Diabetes Association Criteria / Sesti, G; Fiorentino, Tv; Perticone, M; Sciacqua, A; Andreozzi, F; Hribal, Ml; Perticone, F. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 179:(2015), pp. 211-213. [10.1016/j.ijcard.2014.11.055]
Characterization of left ventricular mass in individuals at risk for type 2 diabetes identified by HbA1c levels according to the American Diabetes Association Criteria
Sesti G
;
2015
Abstract
Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are two dysglycemic disorders that have been referred to as categories of increased risk for type 2 diabetes (T2DM) as well as for cardiovascular disease [1]. Recently, the American Diabetes Association (ADA) has proposed a glycated hemoglobin (HbA1c) value of 5.7–6.4% (39–46 mmol/mol) as a new indicator of prediabetes in addition to IFG and IGT [2]. The three glycemic parameters used as measures of dysglycemia, i.e. fasting plasma glucose (FPG), 2-h post-challenge glucose (2-h PG), and HbA1c reflect different features of glucose metabolism with FPG reflecting steady-state glucose metabolism, 2-h PG being an indicator of glycemic response to meal, and HbA1c, an indicator of average blood glucose concentrations over 2–3 months, capturing both fasting and post-meal glycemia. There is evidence that FPG and 2-h PG in the range diagnostic for IFG and IGT have an impact on cardiac geometry and function and are associated with left ventricular hypertrophy (LVH), a well-established predictor of cardiovascular morbidity and mortality.File | Dimensione | Formato | |
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