Post-traumatic stress disorder (PTSD) is a psychiatric disorder whose pathogenesis relies on a maladaptive expression of the memory for a life-threatening experience, characterized by overconsolidation, generalization and impaired extinction, which in turn are responsible of dramatic changes in arousal, mood, anxiety and social behavior. Even if human subjects experiencing a traumatic event during lifetime all show an acute response to the trauma, only a subset (susceptible) of them ultimately develops PTSD, meanwhile the others (resilient) fully recover after the first acute response. The majority of the available animal models of PTSD lacks of a dynamic dissection to better understand how this acute response can turn into PTSD-related maladaptive changes. Here we have implemented the PTSD model we previously developed, to make it suitable to differentiate between susceptible (high responders, HR) and resilient (low responders, LR) rats in terms of overconsolidation, impaired extinction, enhanced anxiety and social impairment after trauma experience. Rats were exposed to inescapable footshocks paired with social isolation. One week after trauma and before starting the extinction sessions, animals were tested in the Open Field (OF) and Social Interaction (SI) tests to search for a predictive variable for HR and LR classification. We found a correlation between the number of crossings in the OF test and the cognitive and behavioral outcomes associated with PTSD-related maladaptive changes, thus suggesting that this parameter is a reliable predictive variable in term of resilience or susceptibility to develop a PTSD-like phenotype after trauma exposure in rats.

Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD) / Colucci, Paola; Marchetta, Enrico; Mancini, GIULIA FEDERICA; Pasquale, Sementilli; Stefano Puglisi Allegra, ; Patrizia, Campolongo. - (2019). ((Intervento presentato al convegno ERA-NET NEURON Mid-Term Symposium tenutosi a Lisbona, Portogallo.

Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)

Paola Colucci;MARCHETTA, ENRICO;Giulia Federica Mancini;
2019

Abstract

Post-traumatic stress disorder (PTSD) is a psychiatric disorder whose pathogenesis relies on a maladaptive expression of the memory for a life-threatening experience, characterized by overconsolidation, generalization and impaired extinction, which in turn are responsible of dramatic changes in arousal, mood, anxiety and social behavior. Even if human subjects experiencing a traumatic event during lifetime all show an acute response to the trauma, only a subset (susceptible) of them ultimately develops PTSD, meanwhile the others (resilient) fully recover after the first acute response. The majority of the available animal models of PTSD lacks of a dynamic dissection to better understand how this acute response can turn into PTSD-related maladaptive changes. Here we have implemented the PTSD model we previously developed, to make it suitable to differentiate between susceptible (high responders, HR) and resilient (low responders, LR) rats in terms of overconsolidation, impaired extinction, enhanced anxiety and social impairment after trauma experience. Rats were exposed to inescapable footshocks paired with social isolation. One week after trauma and before starting the extinction sessions, animals were tested in the Open Field (OF) and Social Interaction (SI) tests to search for a predictive variable for HR and LR classification. We found a correlation between the number of crossings in the OF test and the cognitive and behavioral outcomes associated with PTSD-related maladaptive changes, thus suggesting that this parameter is a reliable predictive variable in term of resilience or susceptibility to develop a PTSD-like phenotype after trauma exposure in rats.
ERA-NET NEURON Mid-Term Symposium
04 Pubblicazione in atti di convegno::04d Abstract in atti di convegno
Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD) / Colucci, Paola; Marchetta, Enrico; Mancini, GIULIA FEDERICA; Pasquale, Sementilli; Stefano Puglisi Allegra, ; Patrizia, Campolongo. - (2019). ((Intervento presentato al convegno ERA-NET NEURON Mid-Term Symposium tenutosi a Lisbona, Portogallo.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1311127
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact