Particle therapy (PT) can exploit heavy ions (such as He, C or O) to enhance the treatment efficacy, profiting from the increased Relative Biological Effectiveness and Oxygen Enhancement Ratio of these projectiles with respect to proton beams. To maximise the gain in tumor control probability a precise online monitoring of the dose release is needed, avoiding unnecessary large safety margins surroundings the tumor volume accounting for possible patient mispositioning or morphological changes with respect to the initial CT scan. The Dose Profiler (DP) detector, presented in this manuscript, is a scintillating fibres tracker of charged secondary particles (mainly protons) that will be operating during the treatment, allowing for an online range monitoring. Such monitoring technique is particularly promising in the context of heavy ions PT, in which the precision achievable by other techniques based on secondary photons detection is limited by the environmental background during the beam delivery. Developed and built at the SBAI department of “La Sapienza”, within the INSIDE collaboration and as part of a Centro Fermi flagship project, the DP is a tracker detector specifically designed and planned for clinical applications inside a PT treatment room. The DP operation in clinical like conditions has been tested with the proton and carbon ions beams of Trento proton-therapy center and of the CNAO facility. In this contribution the detector performances are presented, in the context of the carbon ions monitoring clinical trial that is about to start at the CNAO centre.

Review and performance of the Dose Profiler, a particle therapy treatments online monitor / Traini, G.; Mattei, I.; Battistoni, G.; Bisogni, M. G.; De Simoni, M.; Dong, Y.; Embriaco, A.; Fischetti, M.; Magi, M.; Mancini-Terracciano, C.; Marafini, M.; Mirabelli, R.; Muraro, S.; Patera, V.; Schiavi, A.; Sciubba, A.; Solfaroli Camillocci, E.; Valle, S. M.; Sarti, A.. - In: PHYSICA MEDICA. - ISSN 1120-1797. - 65:(2019), pp. 84-93. [10.1016/j.ejmp.2019.07.010]

Review and performance of the Dose Profiler, a particle therapy treatments online monitor

Traini G.;De Simoni M.;Fischetti M.;Magi M.;Mancini-Terracciano C.;Mirabelli R.;Patera V.;Schiavi A.;Sciubba A.;Solfaroli Camillocci E.;Sarti A.
2019

Abstract

Particle therapy (PT) can exploit heavy ions (such as He, C or O) to enhance the treatment efficacy, profiting from the increased Relative Biological Effectiveness and Oxygen Enhancement Ratio of these projectiles with respect to proton beams. To maximise the gain in tumor control probability a precise online monitoring of the dose release is needed, avoiding unnecessary large safety margins surroundings the tumor volume accounting for possible patient mispositioning or morphological changes with respect to the initial CT scan. The Dose Profiler (DP) detector, presented in this manuscript, is a scintillating fibres tracker of charged secondary particles (mainly protons) that will be operating during the treatment, allowing for an online range monitoring. Such monitoring technique is particularly promising in the context of heavy ions PT, in which the precision achievable by other techniques based on secondary photons detection is limited by the environmental background during the beam delivery. Developed and built at the SBAI department of “La Sapienza”, within the INSIDE collaboration and as part of a Centro Fermi flagship project, the DP is a tracker detector specifically designed and planned for clinical applications inside a PT treatment room. The DP operation in clinical like conditions has been tested with the proton and carbon ions beams of Trento proton-therapy center and of the CNAO facility. In this contribution the detector performances are presented, in the context of the carbon ions monitoring clinical trial that is about to start at the CNAO centre.
Instrumentation for heavy-ion therapy; Particle tracking detectors; Radiation monitoring
01 Pubblicazione su rivista::01a Articolo in rivista
Review and performance of the Dose Profiler, a particle therapy treatments online monitor / Traini, G.; Mattei, I.; Battistoni, G.; Bisogni, M. G.; De Simoni, M.; Dong, Y.; Embriaco, A.; Fischetti, M.; Magi, M.; Mancini-Terracciano, C.; Marafini, M.; Mirabelli, R.; Muraro, S.; Patera, V.; Schiavi, A.; Sciubba, A.; Solfaroli Camillocci, E.; Valle, S. M.; Sarti, A.. - In: PHYSICA MEDICA. - ISSN 1120-1797. - 65:(2019), pp. 84-93. [10.1016/j.ejmp.2019.07.010]
File allegati a questo prodotto
File Dimensione Formato  
1-s2.0-S1120179719301620-main.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 4.53 MB
Formato Adobe PDF
4.53 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1310053
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 15
social impact