Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated. Our results show that the hydrophobic portion of the lipid bilayer strongly influences both the properties and the internalization of glycosylated liposomes.
Structurally related glucosylated liposomes: correlation of physicochemical and biological features / Mauceri, A.; Giansanti, L.; Bozzuto, G.; Condello, M.; Molinari, A.; Galantini, L.; Piozzi, A.; Mancini, G.. - In: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. - ISSN 0005-2736. - 1861:8(2019), pp. 1468-1475. [10.1016/j.bbamem.2019.06.003]
Structurally related glucosylated liposomes: correlation of physicochemical and biological features
Mauceri A.Primo
;Bozzuto G.Membro del Collaboration Group
;Galantini L.Formal Analysis
;Piozzi A.Penultimo
Formal Analysis
;
2019
Abstract
Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated. Our results show that the hydrophobic portion of the lipid bilayer strongly influences both the properties and the internalization of glycosylated liposomes.File | Dimensione | Formato | |
---|---|---|---|
Mauceri_Structurally-related_2019.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
1.7 MB
Formato
Adobe PDF
|
1.7 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.