Serine hydroxymethyltransferase (SHMT) is a member of the fold type I family of vitamin-B6 dependent enzymes, a group of evolutionary related proteins which share the same overall three-dimensional fold. As shown in this study, an evolutionary analysis of the fold type I enzymes suggests that SHMT, L-threonine aldolase and fungal alanine racemase may actually belong to a subgroup of closely related proteins.
L-threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase: structural diversity and uniformity in a subgroup of closely related enzymes catalysing different reactions / Contestabile, R.; Paiardini, A.; Pascarella, S.; Bossa, F.. - In: PROTEIN SCIENCE. - ISSN 0961-8368. - 10:Supplement 1(2001), pp. 145-145. (Intervento presentato al convegno Fourth European Symposium of the Protein society tenutosi a Parigi).
L-threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase: structural diversity and uniformity in a subgroup of closely related enzymes catalysing different reactions
R. contestabile;A. Paiardini;S. Pascarella;F. Bossa
2001
Abstract
Serine hydroxymethyltransferase (SHMT) is a member of the fold type I family of vitamin-B6 dependent enzymes, a group of evolutionary related proteins which share the same overall three-dimensional fold. As shown in this study, an evolutionary analysis of the fold type I enzymes suggests that SHMT, L-threonine aldolase and fungal alanine racemase may actually belong to a subgroup of closely related proteins.| File | Dimensione | Formato | |
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