Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using, neuromuscular blocking agents or dopamine agonists.
Successful treatment of a complicated case of neuroleptic malignant syndrome / A., Lappa; M., Podesta'; O., Capelli; A., Castagna; G., Di Placido; Alampi, Daniela; F., Semeraro. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - STAMPA. - 28:7(2002), pp. 976-977. [10.1007/s00134-002-1241-6]
Successful treatment of a complicated case of neuroleptic malignant syndrome
ALAMPI, DANIELA;
2002
Abstract
Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using, neuromuscular blocking agents or dopamine agonists.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
