To explore the pathogenic association between periodontal disease and rheumatoid arthritis focusing on the role of Porphyromonas gingivalis.RECENT FINDINGS: In the last decades our knowledge about the pathogenesis of rheumatoid arthritis substantially changed. Several evidences demonstrated that the initial production of autoantibodies is not localized in the joint, rather in other immunological-active sites. A central role seems to be played by periodontal disease, in particular because of the ability of P. gingivalis to induce citrullination, the posttranslational modification leading to the production of anticitrullinated protein/peptide antibodies, the most sensitive and specific rheumatoid arthritis biomarker. SUMMARY: The pathogenic role of P. gingivalis has been demonstrated in mouse models in which arthritis was either triggered or worsened in infected animals. P. gingivalis showed its detrimental role not only by inducing citrullination but also by means of other key mechanisms including induction of NETosis, osteoclastogenesis, and Th17 proinflammatory response leading to bone damage and systemic inflammation.

Porphyromonas gingivalis and rheumatoid arthritis / Perricone, Carlo; Ceccarelli, Fulvia; Saccucci, Matteo; Di Carlo, Gabriele; Bogdanos, Dimitrios P; Lucchetti, Ramona; Pilloni, Andrea; Valesini, Guido; Polimeni, Antonella; Conti, Fabrizio. - In: CURRENT OPINION IN RHEUMATOLOGY. - ISSN 1040-8711. - (2019), pp. 1-8. [10.1097/BOR.0000000000000638]

Porphyromonas gingivalis and rheumatoid arthritis

Ceccarelli, Fulvia
Secondo
;
Matteo, Saccucci;Di Carlo, Gabriele;Lucchetti, Ramona;Pilloni, Andrea;Valesini, Guido;Polimeni, Antonella
Penultimo
;
Conti, Fabrizio
Ultimo
2019

Abstract

To explore the pathogenic association between periodontal disease and rheumatoid arthritis focusing on the role of Porphyromonas gingivalis.RECENT FINDINGS: In the last decades our knowledge about the pathogenesis of rheumatoid arthritis substantially changed. Several evidences demonstrated that the initial production of autoantibodies is not localized in the joint, rather in other immunological-active sites. A central role seems to be played by periodontal disease, in particular because of the ability of P. gingivalis to induce citrullination, the posttranslational modification leading to the production of anticitrullinated protein/peptide antibodies, the most sensitive and specific rheumatoid arthritis biomarker. SUMMARY: The pathogenic role of P. gingivalis has been demonstrated in mouse models in which arthritis was either triggered or worsened in infected animals. P. gingivalis showed its detrimental role not only by inducing citrullination but also by means of other key mechanisms including induction of NETosis, osteoclastogenesis, and Th17 proinflammatory response leading to bone damage and systemic inflammation.
2019
porphyromonas gingivalis; inflammation; rheumatoid arthritis
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Porphyromonas gingivalis and rheumatoid arthritis / Perricone, Carlo; Ceccarelli, Fulvia; Saccucci, Matteo; Di Carlo, Gabriele; Bogdanos, Dimitrios P; Lucchetti, Ramona; Pilloni, Andrea; Valesini, Guido; Polimeni, Antonella; Conti, Fabrizio. - In: CURRENT OPINION IN RHEUMATOLOGY. - ISSN 1040-8711. - (2019), pp. 1-8. [10.1097/BOR.0000000000000638]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1301640
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