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Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10-8 with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer / Milne, Rl1; 2, ; Kuchenbaecker, Kb3; 4, ; Michailidou, K3; 5, ; Beesley, J6; Kar, S7; Lindström, S8; 9, ; Hui, S10; Lemaçon, A11; Soucy, P11; Dennis, J3; Jiang, X9; Rostamianfar, A10; Finucane, H9; 12, ; Bolla, Mk3; Mcguffog, L3; Wang, Q3; Aalfs, Cm13; Abctb, Investigators; Adams, M14; Adlard, J15; Agata, S16; Ahmed, S7; Ahsan, H17; Aittomäki, K18; Al-Ejeh, F19; Allen, J3; Ambrosone, Cb20; Amos, Ci21; Andrulis, Il22; 23, ; Anton-Culver, H24; Antonenkova, Nn25; Arndt, V26; Arnold, N27; Aronson, Kj28; Auber, B29; Auer, Pl30; 31, ; Ausems, Mgem32; Azzollini, J33; Bacot, F34; Balmaña, J35; Barile, M36; Barjhoux, L37; Barkardottir, Rb38; 39, ; Barrdahl, M40; Barnes, D3; Barrowdale, D3; Baynes, C7; Beckmann, Mw41; Benitez, J42; 43, 44; Bermisheva, M45; Bernstein, L46; Bignon, Yj47; Blazer, Kr48; Blok, Mj49; Blomqvist, C50; Blot, W51; 52, ; Bobolis, K53; Boeckx, B54; 55, ; Bogdanova, Nv25; 56, 57; Bojesen, A58; Bojesen, Se59; 60, 61; Bonanni, B36; Børresen-Dale, Al62; Bozsik, A63; Bradbury, Ar64; Brand, Js65; Brauch, H66; 67, 68; Brenner, H26; 68, 69; Bressac-de Paillerets, B70; Brewer, C71; Brinton, L72; Broberg, P73; Brooks-Wilson, A74; 75, ; Brunet, J76; Brüning, T77; Burwinkel, B78; 79, ; Buys, Ss80; Byun, J21; Cai, Q51; Caldés, T81; Caligo, Ma82; Campbell, I83; 84, ; Canzian, F85; Caron, O70; Carracedo, A86; 87, ; Carter, Bd88; Castelao, Je89; Castera, L90; Caux-Moncoutier, V91; Chan, Sb; Chang-Claude, J40; 92, ; Chanock, Sj72; Chen, X6; Cheng, Td93; Chiquette, J94; Christiansen, H56; Claes, Kbm95; Clarke, Cl96; Conner, T97; Conroy, Dm7; Cook, J98; Cordina-Duverger, E99; Cornelissen, S100; Coupier, I101; Cox, A102; Cox, Dg103; 104, ; Cross, Ss105; Cuk, K26; Cunningham, Jm106; Czene, K65; Daly, Mb107; Damiola, F37; Darabi, H65; Davidson, R108; De Leeneer, K95; Devilee, P109; 110, ; Dicks, E7; Diez, O111; Ding, Yc46; Ditsch, N112; Doheny, Kf14; Domchek, Sm64; Dorfling, Cm113; Dörk, T57; Dos-Santos-Silva, I114; Dubois, S11; Dugué, Pa1; 2, ; Dumont, M11; Dunning, Am7; Durcan, L115; 116, ; Dwek, M117; Dworniczak, B118; Eccles, D116; Eeles, R119; Ehrencrona, H120; Eilber, U40; Ejlertsen, B121; Ekici, Ab122; Eliassen, Ah123; 124, Embrace; Engel, C125; 126, ; Eriksson, M65; Fachal, L7; Faivre, L127; 128, ; Fasching, Pa41; 129, ; Faust, U130; Figueroa, J72; 131, ; Flesch-Janys, D132; 133, ; Fletcher, O134; Flyger, H135; Foulkes, Wd136; Friedman, E137; 138, ; Fritschi, L139; Frost, D3; Gabrielson, M65; Gaddam, P140; Gammon, Md141; Ganz, Pa142; Gapstur, Sm88; Garber, J143; Garcia-Barberan, V81; García-Sáenz, Ja81; Gaudet, Mm88; Gauthier-Villars, M91; Gehrig, A144; GEMO Study, Collaborators; Georgoulias, V145; Gerdes, Am146; Giles, Gg1; 2, ; Glendon, G22; Godwin, Ak147; Goldberg, Ms148; 149, ; Goldgar, De150; González-Neira, A42; Goodfellow, P151; Greene, Mh152; Alnæs, Gig62; Grip, M153; Gronwald, J154; Grundy, A155; Gschwantler-Kaulich, D156; Guénel, P99; Guo, Q157; Haeberle, L41; Hahnen, E158; 159, 160; Haiman, Ca161; Håkansson, N162; Hallberg, E163; Hamann, U164; Hamel, N34; Hankinson, S165; Hansen, Tvo166; Harrington, P7; Hart, Sn163; Hartikainen, Jm167; 168, 169; Healey, Cs7; Hebon, ; Hein, A41; Helbig, S57; Henderson, A170; Heyworth, J171; Hicks, B172; Hillemanns, P57; Hodgson, S173; Hogervorst, Fb174; Hollestelle, A175; Hooning, Mj175; Hoover, B72; Hopper, Jl2; Hu, C106; Huang, G164; Hulick, Pj176; 177, ; Humphreys, K65; Hunter, Dj9; 124, ; Imyanitov, En178; Isaacs, C179; Iwasaki, M180; Izatt, L181; Jakubowska, A154; James, P84; 182, ; Janavicius, R183; Janni, W184; Jensen, Ub185; John, Em186; 187, ; Johnson, N134; Jones, K172; Jones, M188; Jukkola-Vuorinen, A189; Kaaks, R40; Kabisch, M164; Kaczmarek, K154; Kang, D190; 191, 192; Kast, K193; Kconfab/aocs, Investigators; Keeman, R100; Kerin, Mj194; Kets, Cm195; Keupers, M196; Khan, S197; Khusnutdinova, E45; 198, ; Kiiski, Ji197; Kim, Sw156; Knight, Ja199; 200, ; Konstantopoulou, I201; Kosma, Vm167; 168, 169; Kristensen, Vn62; 202, 203; Kruse, Ta204; Kwong, A205; 206, 207; Lænkholm, Av208; Laitman, Y137; Lalloo, F209; Lambrechts, D54; 55, ; Landsman, K210; Lasset, C211; Lazaro, C212; Le Marchand, L213; Lecarpentier, J3; Lee, A3; Lee, E161; Lee, Jw214; Lee, Mh215; Lejbkowicz, F210; Lesueur, F216; 217, 218; 219, ; Li, J65; Lilyquist, J220; Lincoln, A221; Lindblom, A222; Lissowska, J223; Lo, Wy66; 67, ; Loibl, S224; Long, J51; Loud, Jt152; Lubinski, J154; Luccarini, C7; Lush, M3; Macinnis, Rj1; 2, ; Maishman, T115; 116, ; Makalic, E2; Kostovska, Im225; Malone, Ke226; Manoukian, S33; Manson, Je227; Margolin, S228; Martens, Jwm175; Martinez, Me229; 230, ; Matsuo, K231; 232, ; Mavroudis, D145; Mazoyer, S233; Mclean, C234; Meijers-Heijboer, H13; 235, ; Menéndez, P236; Meyer, J106; Miao, H237; Miller, A238; Miller, N194; Mitchell, G84; 182, ; Montagna, M16; Muir, K239; 240, ; Mulligan, Am241; 242, ; Mulot, C243; Nadesan, S53; Nathanson, Kl64; Nbsc, Collaborators; Neuhausen, Sl46; Nevanlinna, H197; Nevelsteen, I196; Niederacher, D244; Nielsen, Sf59; 60, ; Nordestgaard, Bg59; 60, 61; Norman, A163; Nussbaum, Rl245; Olah, E63; Olopade, Oi246; Olson, Je163; Olswold, C163; Ong, Kr247; Oosterwijk, Jc248; Orr, N134; Osorio, A43; 44, ; Pankratz, Vs249; Papi, L250; Park-Simon, Tw57; Paulsson-Karlsson, Y251; Lloyd, R252; Pedersen, Is253; Peissel, B33; Peixoto, A254; Perez, Jia255; Peterlongo, P256; Peto, J114; Pfeiler, G157; Phelan, Cm257; Pinchev, M210; Plaseska-Karanfilska, D225; Poppe, B95; Porteous, Me258; Prentice, R30; Presneau, N117; Prokofieva, D198; Pugh, E14; Pujana, Ma259; Pylkäs, K260; 261, ; Rack, B112; 184, ; Radice, P262; Rahman, N263; Rantala, J264; Rappaport-Fuerhauser, C156; Rennert, G210; 265, ; Rennert, Hs210; 265, ; Rhenius, V7; Rhiem, K158; 159, 160; Richardson, A266; Rodriguez, Gc267; Romero, A81; 268, ; Romm, J14; Rookus, Ma269; Rudolph, A40; Ruediger, T270; Saloustros, E271; Sanders, J272; Sandler, Dp273; Sangrajrang, S274; Sawyer, Ej275; Schmidt, Df2; Schoemaker, Mj188; Schumacher, F276; Schürmann, P57; Schwentner, L184; Scott, C163; Scott, Rj277; 278, ; Seal, S263; Senter, L279; Seynaeve, C175; Shah, M7; Sharma, P280; Shen, Cy281; 282, ; Sheng, X161; Shimelis, H106; Shrubsole, Mj51; Shu, Xo51; Side, Le283; Singer, Cf156; Sohn, C284; Southey, Mc285; Spinelli, Jj286; 287, ; Spurdle, Ab6; Stegmaier, C288; Stoppa-Lyonnet, D91; Sukiennicki, G154; Surowy, H78; 79, ; Sutter, C289; Swerdlow, A188; 290, ; Szabo, Ci291; Tamimi, Rm9; 123, 124; Tan, Yy156; Taylor, Ja273; 292, ; Tejada, Mi293; Tengström, M167; 294, 295; Teo, Sh296; 297, ; Terry, Mb298; Tessier, Dc34; Teulé, A299; Thöne, K133; Thull, Dl300; Tibiletti, Mg301; Tihomirova, L302; Tischkowitz, M136; 303, ; Toland, Ae304; Tollenaar, Raem305; Tomlinson, I306; Tong, L17; Torres, D164; 307, ; Tranchant, M11; Truong, T99; Tucker, K308; Tung, N309; Tyrer, J7; Ulmer, Hu310; Vachon, C163; van Asperen, Cj311; Van Den Berg, D161; van den Ouweland, Amw312; van Rensburg, Ej113; Varesco, L313; Varon-Mateeva, R314; Vega, A315; 316, ; Viel, A317; Vijai, J221; Vincent, D34; Vollenweider, J106; Walker, L318; Wang, Z72; 319, ; Wang-Gohrke, S184; Wappenschmidt, B158; 159, 160; Weinberg, Cr320; Weitzel, Jn48; Wendt, C228; Wesseling, J100; 272, ; Whittemore, As187; 321, ; Wijnen, Jt110; 312, ; Willett, W124; 322, ; Winqvist, R260; 261, ; Wolk, A162; Wu, Ah161; Xia, L161; Yang, Xr72; Yannoukakos, D201; Zaffaroni, D33; Zheng, W51; Zhu, B172; Ziogas, A24; Ziv, E323; Zorn, Kk301; Gago-Dominguez, M86; 229, ; Mannermaa, A167; 168, 169; Olsson, H73; Teixeira, Mr254; 324, ; Stone, J252; 325, ; Offit, K326; 327, ; Ottini, Laura; Park, Sk190; 192, ; Thomassen, M204; Hall, P65; 329, ; Meindl, A330; Schmutzler, Rk158; 160, ; Droit, A11; Bader, Gd10; Pharoah, Pdp3; 7, ; Couch, Fj106; Easton, Df3; 7, ; Kraft, P9; 124, ; Chenevix-Trench, G6; García-Closas, M72; Schmidt, Mk100; 331, ; Antoniou, Ac3; Simard, J11.. - In: NATURE GENETICS. - ISSN 1061-4036. - (2017), pp. 1767-1781. [10.1038/ng.3785]

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Ottini Laura;
2017

Abstract

Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10-8 with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.
2017
Breast cancer, estrogen receptor, SNPs
01 Pubblicazione su rivista::01a Articolo in rivista
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer / Milne, Rl1; 2, ; Kuchenbaecker, Kb3; 4, ; Michailidou, K3; 5, ; Beesley, J6; Kar, S7; Lindström, S8; 9, ; Hui, S10; Lemaçon, A11; Soucy, P11; Dennis, J3; Jiang, X9; Rostamianfar, A10; Finucane, H9; 12, ; Bolla, Mk3; Mcguffog, L3; Wang, Q3; Aalfs, Cm13; Abctb, Investigators; Adams, M14; Adlard, J15; Agata, S16; Ahmed, S7; Ahsan, H17; Aittomäki, K18; Al-Ejeh, F19; Allen, J3; Ambrosone, Cb20; Amos, Ci21; Andrulis, Il22; 23, ; Anton-Culver, H24; Antonenkova, Nn25; Arndt, V26; Arnold, N27; Aronson, Kj28; Auber, B29; Auer, Pl30; 31, ; Ausems, Mgem32; Azzollini, J33; Bacot, F34; Balmaña, J35; Barile, M36; Barjhoux, L37; Barkardottir, Rb38; 39, ; Barrdahl, M40; Barnes, D3; Barrowdale, D3; Baynes, C7; Beckmann, Mw41; Benitez, J42; 43, 44; Bermisheva, M45; Bernstein, L46; Bignon, Yj47; Blazer, Kr48; Blok, Mj49; Blomqvist, C50; Blot, W51; 52, ; Bobolis, K53; Boeckx, B54; 55, ; Bogdanova, Nv25; 56, 57; Bojesen, A58; Bojesen, Se59; 60, 61; Bonanni, B36; Børresen-Dale, Al62; Bozsik, A63; Bradbury, Ar64; Brand, Js65; Brauch, H66; 67, 68; Brenner, H26; 68, 69; Bressac-de Paillerets, B70; Brewer, C71; Brinton, L72; Broberg, P73; Brooks-Wilson, A74; 75, ; Brunet, J76; Brüning, T77; Burwinkel, B78; 79, ; Buys, Ss80; Byun, J21; Cai, Q51; Caldés, T81; Caligo, Ma82; Campbell, I83; 84, ; Canzian, F85; Caron, O70; Carracedo, A86; 87, ; Carter, Bd88; Castelao, Je89; Castera, L90; Caux-Moncoutier, V91; Chan, Sb; Chang-Claude, J40; 92, ; Chanock, Sj72; Chen, X6; Cheng, Td93; Chiquette, J94; Christiansen, H56; Claes, Kbm95; Clarke, Cl96; Conner, T97; Conroy, Dm7; Cook, J98; Cordina-Duverger, E99; Cornelissen, S100; Coupier, I101; Cox, A102; Cox, Dg103; 104, ; Cross, Ss105; Cuk, K26; Cunningham, Jm106; Czene, K65; Daly, Mb107; Damiola, F37; Darabi, H65; Davidson, R108; De Leeneer, K95; Devilee, P109; 110, ; Dicks, E7; Diez, O111; Ding, Yc46; Ditsch, N112; Doheny, Kf14; Domchek, Sm64; Dorfling, Cm113; Dörk, T57; Dos-Santos-Silva, I114; Dubois, S11; Dugué, Pa1; 2, ; Dumont, M11; Dunning, Am7; Durcan, L115; 116, ; Dwek, M117; Dworniczak, B118; Eccles, D116; Eeles, R119; Ehrencrona, H120; Eilber, U40; Ejlertsen, B121; Ekici, Ab122; Eliassen, Ah123; 124, Embrace; Engel, C125; 126, ; Eriksson, M65; Fachal, L7; Faivre, L127; 128, ; Fasching, Pa41; 129, ; Faust, U130; Figueroa, J72; 131, ; Flesch-Janys, D132; 133, ; Fletcher, O134; Flyger, H135; Foulkes, Wd136; Friedman, E137; 138, ; Fritschi, L139; Frost, D3; Gabrielson, M65; Gaddam, P140; Gammon, Md141; Ganz, Pa142; Gapstur, Sm88; Garber, J143; Garcia-Barberan, V81; García-Sáenz, Ja81; Gaudet, Mm88; Gauthier-Villars, M91; Gehrig, A144; GEMO Study, Collaborators; Georgoulias, V145; Gerdes, Am146; Giles, Gg1; 2, ; Glendon, G22; Godwin, Ak147; Goldberg, Ms148; 149, ; Goldgar, De150; González-Neira, A42; Goodfellow, P151; Greene, Mh152; Alnæs, Gig62; Grip, M153; Gronwald, J154; Grundy, A155; Gschwantler-Kaulich, D156; Guénel, P99; Guo, Q157; Haeberle, L41; Hahnen, E158; 159, 160; Haiman, Ca161; Håkansson, N162; Hallberg, E163; Hamann, U164; Hamel, N34; Hankinson, S165; Hansen, Tvo166; Harrington, P7; Hart, Sn163; Hartikainen, Jm167; 168, 169; Healey, Cs7; Hebon, ; Hein, A41; Helbig, S57; Henderson, A170; Heyworth, J171; Hicks, B172; Hillemanns, P57; Hodgson, S173; Hogervorst, Fb174; Hollestelle, A175; Hooning, Mj175; Hoover, B72; Hopper, Jl2; Hu, C106; Huang, G164; Hulick, Pj176; 177, ; Humphreys, K65; Hunter, Dj9; 124, ; Imyanitov, En178; Isaacs, C179; Iwasaki, M180; Izatt, L181; Jakubowska, A154; James, P84; 182, ; Janavicius, R183; Janni, W184; Jensen, Ub185; John, Em186; 187, ; Johnson, N134; Jones, K172; Jones, M188; Jukkola-Vuorinen, A189; Kaaks, R40; Kabisch, M164; Kaczmarek, K154; Kang, D190; 191, 192; Kast, K193; Kconfab/aocs, Investigators; Keeman, R100; Kerin, Mj194; Kets, Cm195; Keupers, M196; Khan, S197; Khusnutdinova, E45; 198, ; Kiiski, Ji197; Kim, Sw156; Knight, Ja199; 200, ; Konstantopoulou, I201; Kosma, Vm167; 168, 169; Kristensen, Vn62; 202, 203; Kruse, Ta204; Kwong, A205; 206, 207; Lænkholm, Av208; Laitman, Y137; Lalloo, F209; Lambrechts, D54; 55, ; Landsman, K210; Lasset, C211; Lazaro, C212; Le Marchand, L213; Lecarpentier, J3; Lee, A3; Lee, E161; Lee, Jw214; Lee, Mh215; Lejbkowicz, F210; Lesueur, F216; 217, 218; 219, ; Li, J65; Lilyquist, J220; Lincoln, A221; Lindblom, A222; Lissowska, J223; Lo, Wy66; 67, ; Loibl, S224; Long, J51; Loud, Jt152; Lubinski, J154; Luccarini, C7; Lush, M3; Macinnis, Rj1; 2, ; Maishman, T115; 116, ; Makalic, E2; Kostovska, Im225; Malone, Ke226; Manoukian, S33; Manson, Je227; Margolin, S228; Martens, Jwm175; Martinez, Me229; 230, ; Matsuo, K231; 232, ; Mavroudis, D145; Mazoyer, S233; Mclean, C234; Meijers-Heijboer, H13; 235, ; Menéndez, P236; Meyer, J106; Miao, H237; Miller, A238; Miller, N194; Mitchell, G84; 182, ; Montagna, M16; Muir, K239; 240, ; Mulligan, Am241; 242, ; Mulot, C243; Nadesan, S53; Nathanson, Kl64; Nbsc, Collaborators; Neuhausen, Sl46; Nevanlinna, H197; Nevelsteen, I196; Niederacher, D244; Nielsen, Sf59; 60, ; Nordestgaard, Bg59; 60, 61; Norman, A163; Nussbaum, Rl245; Olah, E63; Olopade, Oi246; Olson, Je163; Olswold, C163; Ong, Kr247; Oosterwijk, Jc248; Orr, N134; Osorio, A43; 44, ; Pankratz, Vs249; Papi, L250; Park-Simon, Tw57; Paulsson-Karlsson, Y251; Lloyd, R252; Pedersen, Is253; Peissel, B33; Peixoto, A254; Perez, Jia255; Peterlongo, P256; Peto, J114; Pfeiler, G157; Phelan, Cm257; Pinchev, M210; Plaseska-Karanfilska, D225; Poppe, B95; Porteous, Me258; Prentice, R30; Presneau, N117; Prokofieva, D198; Pugh, E14; Pujana, Ma259; Pylkäs, K260; 261, ; Rack, B112; 184, ; Radice, P262; Rahman, N263; Rantala, J264; Rappaport-Fuerhauser, C156; Rennert, G210; 265, ; Rennert, Hs210; 265, ; Rhenius, V7; Rhiem, K158; 159, 160; Richardson, A266; Rodriguez, Gc267; Romero, A81; 268, ; Romm, J14; Rookus, Ma269; Rudolph, A40; Ruediger, T270; Saloustros, E271; Sanders, J272; Sandler, Dp273; Sangrajrang, S274; Sawyer, Ej275; Schmidt, Df2; Schoemaker, Mj188; Schumacher, F276; Schürmann, P57; Schwentner, L184; Scott, C163; Scott, Rj277; 278, ; Seal, S263; Senter, L279; Seynaeve, C175; Shah, M7; Sharma, P280; Shen, Cy281; 282, ; Sheng, X161; Shimelis, H106; Shrubsole, Mj51; Shu, Xo51; Side, Le283; Singer, Cf156; Sohn, C284; Southey, Mc285; Spinelli, Jj286; 287, ; Spurdle, Ab6; Stegmaier, C288; Stoppa-Lyonnet, D91; Sukiennicki, G154; Surowy, H78; 79, ; Sutter, C289; Swerdlow, A188; 290, ; Szabo, Ci291; Tamimi, Rm9; 123, 124; Tan, Yy156; Taylor, Ja273; 292, ; Tejada, Mi293; Tengström, M167; 294, 295; Teo, Sh296; 297, ; Terry, Mb298; Tessier, Dc34; Teulé, A299; Thöne, K133; Thull, Dl300; Tibiletti, Mg301; Tihomirova, L302; Tischkowitz, M136; 303, ; Toland, Ae304; Tollenaar, Raem305; Tomlinson, I306; Tong, L17; Torres, D164; 307, ; Tranchant, M11; Truong, T99; Tucker, K308; Tung, N309; Tyrer, J7; Ulmer, Hu310; Vachon, C163; van Asperen, Cj311; Van Den Berg, D161; van den Ouweland, Amw312; van Rensburg, Ej113; Varesco, L313; Varon-Mateeva, R314; Vega, A315; 316, ; Viel, A317; Vijai, J221; Vincent, D34; Vollenweider, J106; Walker, L318; Wang, Z72; 319, ; Wang-Gohrke, S184; Wappenschmidt, B158; 159, 160; Weinberg, Cr320; Weitzel, Jn48; Wendt, C228; Wesseling, J100; 272, ; Whittemore, As187; 321, ; Wijnen, Jt110; 312, ; Willett, W124; 322, ; Winqvist, R260; 261, ; Wolk, A162; Wu, Ah161; Xia, L161; Yang, Xr72; Yannoukakos, D201; Zaffaroni, D33; Zheng, W51; Zhu, B172; Ziogas, A24; Ziv, E323; Zorn, Kk301; Gago-Dominguez, M86; 229, ; Mannermaa, A167; 168, 169; Olsson, H73; Teixeira, Mr254; 324, ; Stone, J252; 325, ; Offit, K326; 327, ; Ottini, Laura; Park, Sk190; 192, ; Thomassen, M204; Hall, P65; 329, ; Meindl, A330; Schmutzler, Rk158; 160, ; Droit, A11; Bader, Gd10; Pharoah, Pdp3; 7, ; Couch, Fj106; Easton, Df3; 7, ; Kraft, P9; 124, ; Chenevix-Trench, G6; García-Closas, M72; Schmidt, Mk100; 331, ; Antoniou, Ac3; Simard, J11.. - In: NATURE GENETICS. - ISSN 1061-4036. - (2017), pp. 1767-1781. [10.1038/ng.3785]
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