This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism, which is a complex multifactorial disorder. There is a large body of evidence showing that alcohol can modify gene expression through epigenetic processes, namely DNA methylation and nucleosomal remodeling via histone modifications. In that regard, chronic exposure to ethanol modifies DNA and histone methylation, histone acetylation, and microRNA expression. The alcohol-mediated chromatin remodeling in the brain promotes the transition from use to abuse and addiction. Unravelling the multiplex pattern of molecular modifications induced by ethanol could support the development of new therapies for alcoholism and drug addiction targeting epigenetic processes.

How alcohol drinking affects our genes: an epigenetic point of view / Ciafrè, Stefania; Carito, Valentina; Ferraguti, Giampiero; Greco, Antonio; Nikov Chaldakov, George; Fiore, Marco; Ceccanti, Mauro. - In: BIOCHEMISTRY AND CELL BIOLOGY. - ISSN 0829-8211. - 4:97(2018), pp. 345-356. [10.1139/bcb-2018-0248]

How alcohol drinking affects our genes: an epigenetic point of view

Giampiero Ferraguti
;
Antonio Greco;Marco Fiore
;
Mauro Ceccanti
2018

Abstract

This work highlights recent studies in epigenetic mechanisms that play a role in alcoholism, which is a complex multifactorial disorder. There is a large body of evidence showing that alcohol can modify gene expression through epigenetic processes, namely DNA methylation and nucleosomal remodeling via histone modifications. In that regard, chronic exposure to ethanol modifies DNA and histone methylation, histone acetylation, and microRNA expression. The alcohol-mediated chromatin remodeling in the brain promotes the transition from use to abuse and addiction. Unravelling the multiplex pattern of molecular modifications induced by ethanol could support the development of new therapies for alcoholism and drug addiction targeting epigenetic processes.
2018
alcohol; addiction; epigenetics
01 Pubblicazione su rivista::01a Articolo in rivista
How alcohol drinking affects our genes: an epigenetic point of view / Ciafrè, Stefania; Carito, Valentina; Ferraguti, Giampiero; Greco, Antonio; Nikov Chaldakov, George; Fiore, Marco; Ceccanti, Mauro. - In: BIOCHEMISTRY AND CELL BIOLOGY. - ISSN 0829-8211. - 4:97(2018), pp. 345-356. [10.1139/bcb-2018-0248]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1301280
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