Parental psychopathological risk is considered as one of the most crucial features associated with epigenetic modifications in o↵spring, which in turn are thought to be related to their emotional/behavioral profiles. The dopamine active transporter (DAT) gene is suggested to play a significant role in a↵ective/behavioral regulation. On the basis of the previous literature, we aimed at verifying whether children’s DAT1 polymorphisms moderated the relationship between parents’ psychological profiles, children’s emotional/behavioral functioning, and DAT1 methylation in a normative sample of 79 families with school-age children (Ntot = 237). Children’s biological samples were collected through buccal swabs, while Symptom Check-List-90 item Revised, Adult Self Report, and Child Behavior Check-List/6–18 was administered to assess parental and children’s psychological functioning. We found that higher maternal externalizing problems predicted the following: higher levels of children’s DAT1 methylation at M1, but only among children with 10/10 genotype; higher levels of methylation at M2 among children with 10/10 genotype; while lower levels for children with a 9-repeat allele. There was also a positive relationship between fathers’ externalizing problems and children’s externalizing problems, only for children with a 9-repeat allele. Our findings support emerging evidence of the complex interplay between genetic and environmental factors in shaping children’ emotional/behavioral functioning, contributing to the knowledge of risk variables for a child’s development and psychological well-being

Children’s DAT1 polymorphism moderates the relationship between parents’ psychological profiles, children’s DAT methylation, and their emotional/behavioral functioning in a normative sample / Cimino, Silvia; Cerniglia, Luca; Ballarotto, Giulia; Marzilli, Eleonora; Pascale, Esterina; D'Addario, Claudio; Adriani, Walter; Giovanni Icro Maremmani, Angelo; Tambelli, Renata. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 16:(2019). [10.3390/ijerph16142567]

Children’s DAT1 polymorphism moderates the relationship between parents’ psychological profiles, children’s DAT methylation, and their emotional/behavioral functioning in a normative sample

silvia cimino;luca cerniglia
;
Giulia ballarotto;Eleonora Marzilli;Esterina Pascale;Renata Tambelli
2019

Abstract

Parental psychopathological risk is considered as one of the most crucial features associated with epigenetic modifications in o↵spring, which in turn are thought to be related to their emotional/behavioral profiles. The dopamine active transporter (DAT) gene is suggested to play a significant role in a↵ective/behavioral regulation. On the basis of the previous literature, we aimed at verifying whether children’s DAT1 polymorphisms moderated the relationship between parents’ psychological profiles, children’s emotional/behavioral functioning, and DAT1 methylation in a normative sample of 79 families with school-age children (Ntot = 237). Children’s biological samples were collected through buccal swabs, while Symptom Check-List-90 item Revised, Adult Self Report, and Child Behavior Check-List/6–18 was administered to assess parental and children’s psychological functioning. We found that higher maternal externalizing problems predicted the following: higher levels of children’s DAT1 methylation at M1, but only among children with 10/10 genotype; higher levels of methylation at M2 among children with 10/10 genotype; while lower levels for children with a 9-repeat allele. There was also a positive relationship between fathers’ externalizing problems and children’s externalizing problems, only for children with a 9-repeat allele. Our findings support emerging evidence of the complex interplay between genetic and environmental factors in shaping children’ emotional/behavioral functioning, contributing to the knowledge of risk variables for a child’s development and psychological well-being
2019
methylation; dopamine transporter; genotype; psychopathological symptoms
01 Pubblicazione su rivista::01a Articolo in rivista
Children’s DAT1 polymorphism moderates the relationship between parents’ psychological profiles, children’s DAT methylation, and their emotional/behavioral functioning in a normative sample / Cimino, Silvia; Cerniglia, Luca; Ballarotto, Giulia; Marzilli, Eleonora; Pascale, Esterina; D'Addario, Claudio; Adriani, Walter; Giovanni Icro Maremmani, Angelo; Tambelli, Renata. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 16:(2019). [10.3390/ijerph16142567]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1301003
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