The different presentation of adrenocortical tumors in benign adenoma (ACA) or adrenocortical carcinoma (ACC) is related to the variability at the molecular level. The insulin-like growth factor (IGF) system is one of the most frequently altered pathways in ACC. In this review we will critically analyze the evidence regarding the pathogenic role of the IGF system in adrenal tumorigenesis, focusing on ACC. We will also examine the pre-clinical and clinical studies which investigated the targeting of the IGF system as a therapeutic approach in ACC.
The role of Insulin-like Growth Factor (IGF) system in the adrenocortical tumors / Altieri, Barbara; Colao, Annamaria; Faggiano, Antongiulio. - In: MINERVA ENDOCRINOLOGICA. - ISSN 0391-1977. - (2018). [10.23736/S0391-1977.18.02882-1]
The role of Insulin-like Growth Factor (IGF) system in the adrenocortical tumors
Faggiano, Antongiulio
2018
Abstract
The different presentation of adrenocortical tumors in benign adenoma (ACA) or adrenocortical carcinoma (ACC) is related to the variability at the molecular level. The insulin-like growth factor (IGF) system is one of the most frequently altered pathways in ACC. In this review we will critically analyze the evidence regarding the pathogenic role of the IGF system in adrenal tumorigenesis, focusing on ACC. We will also examine the pre-clinical and clinical studies which investigated the targeting of the IGF system as a therapeutic approach in ACC.| File | Dimensione | Formato | |
|---|---|---|---|
|
Faggiano_Role-of-insulin.pdf
accesso aperto
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
631.41 kB
Formato
Adobe PDF
|
631.41 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
