The nerve growth factor (NGF) belongs to a family of proteins termed neurotrophins, consisting of NGF, brain-derived neuro- trophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. Today, NGF is well recognized to mediate a large number of trophobiological actions resulting in neurotrophic, immunotrophic and/or metabotrophic effects. The pathobiology of neurode- generative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infection have in common the effect of altering the brain levels of neurotrophins and in particular NGF. The involvement of NGF and its TrkA receptor in these pathologies and the recent promising results of NGF therapies are presented and discussed.
Nerve growth factor in brain diseases / Stefania, Ciafrè; Valentina, Carito; Ferraguti, Giampiero; Greco, Antonio; Ralli, Massimo; Aloe, GIAN LUIGI; George, Chaldakov; Messina, Marisa Patrizia; Attilia, Maria Luisa; Rosaria, Ceccarelli; Tarani, Luigi; Ceccanti, Mauro; Fiore, Marco. - In: BIOMEDICAL REVIEWS. - ISSN 1314-1929. - 29:(2018), pp. 1-16. [10.14748/bmr.v29.5845]
Nerve growth factor in brain diseases
Giampiero Ferraguti;Antonio Greco;Massimo Ralli;ALOE, GIAN LUIGI;Marisa Patrizia Messina;Maria Luisa Attilia;Luigi Tarani;Mauro CeccantiPenultimo
;Marco Fiore
Ultimo
2018
Abstract
The nerve growth factor (NGF) belongs to a family of proteins termed neurotrophins, consisting of NGF, brain-derived neuro- trophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. Today, NGF is well recognized to mediate a large number of trophobiological actions resulting in neurotrophic, immunotrophic and/or metabotrophic effects. The pathobiology of neurode- generative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infection have in common the effect of altering the brain levels of neurotrophins and in particular NGF. The involvement of NGF and its TrkA receptor in these pathologies and the recent promising results of NGF therapies are presented and discussed.File | Dimensione | Formato | |
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