Possibility for application of extracellular protease of micromycete aspergillus ochraceus for determining factor X content in human blood plasma

It has been shown that activity of factor X activity determined in normal plasma using Aspergillus ochraceus protease is comparable with the activity of a commercial analogue, a protease from Russell’s viper venom (RVV-X®). It was revealed that the protease of A. ochraceus along with the RVV-X® preparation can be used to determine the content of factor X in the plasma with its reduced content. A study of the protease activity of A. ochraceus, an activator to factor X, showed that it is slightly higher compared to the snake venom preparation, which can make A. ochraceus protease a promising substitute for the snake activator in diagnostics for determining the content of factor X.