Methiopropamine (MPA) is a structural analogue of methamphetamine and belongs to the category of the novel psychoactive substances. To the best of our knowledge, no experimental study has been performed to evaluate the organ damage evoked by MPA administration in an animal model. Therefore, the main purpose of the present study was to investigate the histological changes in CD-1 male mice following the chronic administration of MPA. MPA-chronically treated mice showed myocardial damage with features consistent with repeated episodes of ischemia and a pattern of kidney damage and gastrointestinal ischemia, with ischemic-necrotic lesions of variable extent. In agreement with the analogies between MPA and methamphetamine, we link organ damage secondary to MPA administration to the vasoconstrictive effect exhibited by both compounds. Chronically MPA-treated mice did not show changes in body weight, food intake, thermoregulation, muscular strength and motor coordination in the accelerod test. However, acute MPA administration significantly increased their heart rate and promoted vasoconstriction, which were associated with the sudden death of a subset of animals (40% of all chronically treated mice). In conclusion, the present study demonstrates that MPA consumption could induce health hazards, highlighting the risk of sudden catastrophic events; therefore, clinicians should be aware of these data and consider MPA screening when no other drug is identified by a urine drug screen.

Phenotypic effects of chronic and acute use of methiopropamine in a mouse model / Foti, F.; Marti, M.; Ossato, A.; Bilel, S.; Sangiorgi, E.; Botre, F.; Cerbelli, B.; Baldi, A.; De-Giorgio, F.. - In: INTERNATIONAL JOURNAL OF LEGAL MEDICINE. - ISSN 0937-9827. - 133:3(2019), pp. 811-820. [10.1007/s00414-018-1891-8]

Phenotypic effects of chronic and acute use of methiopropamine in a mouse model

Botre F.;Cerbelli B.;
2019

Abstract

Methiopropamine (MPA) is a structural analogue of methamphetamine and belongs to the category of the novel psychoactive substances. To the best of our knowledge, no experimental study has been performed to evaluate the organ damage evoked by MPA administration in an animal model. Therefore, the main purpose of the present study was to investigate the histological changes in CD-1 male mice following the chronic administration of MPA. MPA-chronically treated mice showed myocardial damage with features consistent with repeated episodes of ischemia and a pattern of kidney damage and gastrointestinal ischemia, with ischemic-necrotic lesions of variable extent. In agreement with the analogies between MPA and methamphetamine, we link organ damage secondary to MPA administration to the vasoconstrictive effect exhibited by both compounds. Chronically MPA-treated mice did not show changes in body weight, food intake, thermoregulation, muscular strength and motor coordination in the accelerod test. However, acute MPA administration significantly increased their heart rate and promoted vasoconstriction, which were associated with the sudden death of a subset of animals (40% of all chronically treated mice). In conclusion, the present study demonstrates that MPA consumption could induce health hazards, highlighting the risk of sudden catastrophic events; therefore, clinicians should be aware of these data and consider MPA screening when no other drug is identified by a urine drug screen.
2019
Gastrointestinal tract; kidney; methiopropamine; mice; myocardium; novel psychoactive substances; animals; death, sudden; heart rate; intestines; ischemia; kidney; male; methamphetamine; mice, inbred ICR; models, animal; myocardium; psychotropic drugs; street drugs; thiophenes; vasoconstriction
01 Pubblicazione su rivista::01a Articolo in rivista
Phenotypic effects of chronic and acute use of methiopropamine in a mouse model / Foti, F.; Marti, M.; Ossato, A.; Bilel, S.; Sangiorgi, E.; Botre, F.; Cerbelli, B.; Baldi, A.; De-Giorgio, F.. - In: INTERNATIONAL JOURNAL OF LEGAL MEDICINE. - ISSN 0937-9827. - 133:3(2019), pp. 811-820. [10.1007/s00414-018-1891-8]
File allegati a questo prodotto
File Dimensione Formato  
Botré_Phenotypic-effects.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.46 MB
Formato Adobe PDF
1.46 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1291267
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 15
social impact