Liver abscesses containing hypervirulent Klebsiella pneumoniae have emerged during the past 2 decades, originally in Southeast Asia and then worldwide. We hypothesized that hypervirulent K. pneumoniae might also be emerging in France. In a retrospective, monocentric, cohort study, we analyzed characteristics and outcomes for 199 consecutive patients in Paris, France, with liver abscesses during 2010−2015. We focused on 31 patients with abscesses containing K. pneumoniae. This bacterium was present in most (14/27, 52%) cryptogenic liver abscesses. Cryptogenic K. pneumoniae abscesses were more frequently community-acquired (p<0.00001) and monomicrobial (p = 0.008), less likely to involve cancer patients (p<0.01), and relapsed less often (p<0.01) than did noncryptogenic K. pneumoniae liver abscesses. K. pneumoniae isolates from cryptogenic abscesses belonged to either the K1 or K2 serotypes and had more virulence factors than noncryptogenic K. pneumoniae isolates. Hypervirulent K. pneumoniae are emerging as the main pathogen isolated from cryptogenic liver abscesses in the study area.

Hypervirulent klebsiella pneumoniae in cryptogenic liver abscesses, Paris, France / Rossi, B.; GASPERINI ZACCO, MARIA LUDOVICA; Leflon-Guibout, V.; Gioanni, A.; de Lastours, V.; Rossi, G.; Dokmak, S.; Ronot, M.; Roux, O.; Nicolas-Chanoine, M. -H.; Fantin, B.; Lefort, A.. - In: EMERGING INFECTIOUS DISEASES. - ISSN 1080-6040. - 24:2(2018), pp. 221-229. [10.3201/eid2402.170957]

Hypervirulent klebsiella pneumoniae in cryptogenic liver abscesses, Paris, France

Gasperini;
2018

Abstract

Liver abscesses containing hypervirulent Klebsiella pneumoniae have emerged during the past 2 decades, originally in Southeast Asia and then worldwide. We hypothesized that hypervirulent K. pneumoniae might also be emerging in France. In a retrospective, monocentric, cohort study, we analyzed characteristics and outcomes for 199 consecutive patients in Paris, France, with liver abscesses during 2010−2015. We focused on 31 patients with abscesses containing K. pneumoniae. This bacterium was present in most (14/27, 52%) cryptogenic liver abscesses. Cryptogenic K. pneumoniae abscesses were more frequently community-acquired (p<0.00001) and monomicrobial (p = 0.008), less likely to involve cancer patients (p<0.01), and relapsed less often (p<0.01) than did noncryptogenic K. pneumoniae liver abscesses. K. pneumoniae isolates from cryptogenic abscesses belonged to either the K1 or K2 serotypes and had more virulence factors than noncryptogenic K. pneumoniae isolates. Hypervirulent K. pneumoniae are emerging as the main pathogen isolated from cryptogenic liver abscesses in the study area.
2018
France; Klebsiella pneumoniae; Paris; bacteria; cryptogenic liver abscesses; hypervirulent; Cohort Studies; France; Hospitals; Humans; Klebsiella Infections; Klebsiella pneumoniae; Liver Abscess; Retrospective Studies; Virulence
01 Pubblicazione su rivista::01a Articolo in rivista
Hypervirulent klebsiella pneumoniae in cryptogenic liver abscesses, Paris, France / Rossi, B.; GASPERINI ZACCO, MARIA LUDOVICA; Leflon-Guibout, V.; Gioanni, A.; de Lastours, V.; Rossi, G.; Dokmak, S.; Ronot, M.; Roux, O.; Nicolas-Chanoine, M. -H.; Fantin, B.; Lefort, A.. - In: EMERGING INFECTIOUS DISEASES. - ISSN 1080-6040. - 24:2(2018), pp. 221-229. [10.3201/eid2402.170957]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1288769
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