Aim: Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression and HPV-attributable fraction in recent consecutive OPSCCs. Materials & methods: 140 OPSCCs were analyzed for HPV-DNA using the INNO-LiPA assay and p16 overexpression using CINtec® Histology kit. Results: HPV-DNA prevalence was 40.7%, and was significantly higher in basaloid and nonkeratinizing SCCs, but similar in tonsillar and base of tongue SCCs. Moreover, 98.0% of the HPV-positive OPSCCs overexpressed p16, compared with 12.3% of the HPV-negative cases (p < 0.0001). Based on HPV-DNA and p16 double positivity, 39.8% of the cases were HPV related. Conclusion: The high estimate of the HPV-attributable fraction suggests that a substantial proportion of OPSCC patients may be managed less intensively.

Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: A case series from 2010 to 2014 / Dona, M. G.; Spriano, G.; Pichi, B.; Rollo, F.; Laquintana, V.; Covello, R.; Pellini, R.; Giuliani, M.; Pescarmona, E.; Benevolo, M.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 10:8(2015), pp. 1283-1291. [10.2217/FMB.15.55]

Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: A case series from 2010 to 2014

Laquintana V.;Pescarmona E.;
2015

Abstract

Aim: Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression and HPV-attributable fraction in recent consecutive OPSCCs. Materials & methods: 140 OPSCCs were analyzed for HPV-DNA using the INNO-LiPA assay and p16 overexpression using CINtec® Histology kit. Results: HPV-DNA prevalence was 40.7%, and was significantly higher in basaloid and nonkeratinizing SCCs, but similar in tonsillar and base of tongue SCCs. Moreover, 98.0% of the HPV-positive OPSCCs overexpressed p16, compared with 12.3% of the HPV-negative cases (p < 0.0001). Based on HPV-DNA and p16 double positivity, 39.8% of the cases were HPV related. Conclusion: The high estimate of the HPV-attributable fraction suggests that a substantial proportion of OPSCC patients may be managed less intensively.
2015
head and neck neoplasms; human papillomavirus; oropharyngeal neoplasms; p16INK4 protein; prevalence
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Human papillomavirus infection and p16 overexpression in oropharyngeal squamous cell carcinoma: A case series from 2010 to 2014 / Dona, M. G.; Spriano, G.; Pichi, B.; Rollo, F.; Laquintana, V.; Covello, R.; Pellini, R.; Giuliani, M.; Pescarmona, E.; Benevolo, M.. - In: FUTURE MICROBIOLOGY. - ISSN 1746-0913. - 10:8(2015), pp. 1283-1291. [10.2217/FMB.15.55]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1288361
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