In this review, we advocate a dimensional approach on the basis of candidate endophenotypes to the development of animal models of post-traumatic stress disorder (PTSD) capable of including genetic liability factors, variations in symptoms profile and underlying neurobiological mechanisms, and specific comorbidities. Results from the clinical literature pointed to two candidate endophenotypes of PTSD: low sensory gating and high waiting impulsivity. Findings of comparative studies in mice of two inbred strains characterized by different expressions of the two candidate endophenotypes showed different strain-specific neural and behavioral effects of stress experiences. Thus, mice of the standard C57BL/6J strain show stress-induced helplessness, stress-learned helplessness, and stress-extinction-resistant conditioned freezing. Instead, mice of the genetically unrelated DBA/2J strain, expressing both candidate endophenotypes, show stress-induced extinction-resistant avoidance and neural and behavioral phenotypes promoted by prolonged exposure to addictive drugs. These strain differences are in line with evidence of associations between genetic variants and specific stress-promoted pathological profiles in PTSD, support a role of genotype in determining different PTSD comorbidities, and offer the means to investigate specific pathogenic processes

Animal models of liability to post-traumatic stress disorder. Going beyond fear memory / Cabib, Simona; Orsini, Cristina; PUGLISI ALLEGRA, Stefano. - In: BEHAVIOURAL PHARMACOLOGY. - ISSN 0955-8810. - (2019). [10.1097/FBP.0000000000000475]

Animal models of liability to post-traumatic stress disorder. Going beyond fear memory

Simona Cabib
Primo
;
Cristina Orsini
Secondo
;
Stefano Puglisi-Allegra
Ultimo
2019

Abstract

In this review, we advocate a dimensional approach on the basis of candidate endophenotypes to the development of animal models of post-traumatic stress disorder (PTSD) capable of including genetic liability factors, variations in symptoms profile and underlying neurobiological mechanisms, and specific comorbidities. Results from the clinical literature pointed to two candidate endophenotypes of PTSD: low sensory gating and high waiting impulsivity. Findings of comparative studies in mice of two inbred strains characterized by different expressions of the two candidate endophenotypes showed different strain-specific neural and behavioral effects of stress experiences. Thus, mice of the standard C57BL/6J strain show stress-induced helplessness, stress-learned helplessness, and stress-extinction-resistant conditioned freezing. Instead, mice of the genetically unrelated DBA/2J strain, expressing both candidate endophenotypes, show stress-induced extinction-resistant avoidance and neural and behavioral phenotypes promoted by prolonged exposure to addictive drugs. These strain differences are in line with evidence of associations between genetic variants and specific stress-promoted pathological profiles in PTSD, support a role of genotype in determining different PTSD comorbidities, and offer the means to investigate specific pathogenic processes
2019
animal models; avoidance; endophenotype; genetics; impulsivity; mouse; stress coping
01 Pubblicazione su rivista::01a Articolo in rivista
Animal models of liability to post-traumatic stress disorder. Going beyond fear memory / Cabib, Simona; Orsini, Cristina; PUGLISI ALLEGRA, Stefano. - In: BEHAVIOURAL PHARMACOLOGY. - ISSN 0955-8810. - (2019). [10.1097/FBP.0000000000000475]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1287725
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