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The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the blaOXA-58 gene showed genetic variability, with the presence in several isolates of multiple copies of the blaOXA-58 gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii / Bertini, A; Poirel, L; Bernabeu, S; Fortini, D; Villa, L; Nordmann, P; Carattoli, A.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 51:7(2007), pp. 2324-2328. [10.1128/AAC.01502-06]

Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii

Carattoli A.
2007

Abstract

The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene blaOXA-58 but showed variable levels of resistance to carbapenems. Analysis of sequences surrounding the blaOXA-58 gene showed genetic variability, with the presence in several isolates of multiple copies of the blaOXA-58 gene; this extra copy number was likely related to an IS26-mediated transposition or recombination process. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
2007
carbapenem derivative; ceftazidime; imipenem; meropenem; antiinfective agent; bacterial DNA; beta lactamase; carbapenem derivative; oxacillinase; unclassified drug, Acinetobacter baumannii; antibiotic resistance; article; bacterial gene; bacterial genetics; bacterium isolate; bla OXA 58 gene; gene sequence; genetic variability; Italy; minimum inhibitory concentration; nonhuman; nucleotide sequence; plasmid; priority journal; university hospital; antibiotic resistance; biosynthesis; DNA sequence; drug effect; enzymology; gene dosage; genetics; human; isolation and purification; microbiological examination; molecular cloning; nucleic acid amplification; polymerase chain reaction, Acinetobacter baumannii; Anti-Bacterial Agents; Base Sequence; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cloning, Molecular; DNA, Bacterial; Gene Dosage; Genes, Bacterial; Humans; Microbial Sensitivity Tests; Nucleic Acid Amplification Techniques; Plasmids; Polymerase Chain Reaction; Sequence Analysis, DNA; Variation (Genetics)
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Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii / Bertini, A; Poirel, L; Bernabeu, S; Fortini, D; Villa, L; Nordmann, P; Carattoli, A.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 51:7(2007), pp. 2324-2328. [10.1128/AAC.01502-06]
01a Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1285084
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