The selective pressure imposed by the use of antimicrobials in both human and veterinary medicine promotes the spread of multiple antimicrobial resistance. The dissemination of antimicrobial resistance in Salmonella enterica strains, causing severe enteritis in human, has been reported worldwide and is largely attributed to conjugative DNA exchange. In the present review, the relevance of plasmids to the dissemination of antimicrobial resistance in S. enterica is discussed. Recent examples of plasmid-mediated resistance to expanded-spectrum cephalosporins are reported to illustrate the severity of current situation in enteric pathogens. The exchanges between plasmid(s) and the bacterial chromosome and the integration of resistance genes into specialised genetic elements, called integrons, play a major role in acquisition and dissemination of resistance genes. The evolution of a plasmid through the acquisition of integrons is reported, describing novel mechanisms for short-term accumulation of resistance determinants in plasmids circulating in Salmonella.

Plasmid-mediated antimicrobial resistance in Salmonella enterica / Carattoli, A.. - In: CURRENT ISSUES IN MOLECULAR BIOLOGY. - ISSN 1467-3037. - 5:4(2003), pp. 113-122.

Plasmid-mediated antimicrobial resistance in Salmonella enterica

Carattoli, A.
2003

Abstract

The selective pressure imposed by the use of antimicrobials in both human and veterinary medicine promotes the spread of multiple antimicrobial resistance. The dissemination of antimicrobial resistance in Salmonella enterica strains, causing severe enteritis in human, has been reported worldwide and is largely attributed to conjugative DNA exchange. In the present review, the relevance of plasmids to the dissemination of antimicrobial resistance in S. enterica is discussed. Recent examples of plasmid-mediated resistance to expanded-spectrum cephalosporins are reported to illustrate the severity of current situation in enteric pathogens. The exchanges between plasmid(s) and the bacterial chromosome and the integration of resistance genes into specialised genetic elements, called integrons, play a major role in acquisition and dissemination of resistance genes. The evolution of a plasmid through the acquisition of integrons is reported, describing novel mechanisms for short-term accumulation of resistance determinants in plasmids circulating in Salmonella.
2003
aminoglycoside; ampicillin; antiinfective agent; apramycin; bacterial DNA; beta lactam antibiotic; carbapenem; ceftiofur; ceftriaxone; cephalosporin derivative; chloramphenicol; cotrimoxazole; double stranded DNA; gentamicin; kanamycin; quinoline derived antiinfective agent; spectinomycin; streptomycin; sulfonamide; tetracycline, animal; antibiotic resistance; bacterial chromosome; bacterial strain; bacterial virulence; bacterium isolation; DNA modification; drug effect; gene replication; gene transfer; genetic code; genetics; human; integron; microbiological examination; molecular evolution; multidrug resistance; nonhuman; plasmid; point mutation; review; Salmonella enterica; species difference; strain difference; transposon, Animals; Anti-Bacterial Agents; DNA Transposable Elements; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Evolution, Molecular; Humans; Integrons; Microbial Sensitivity Tests; Plasmids; Salmonella enterica, Animalia; Bacteria (microorganisms); Prokaryota; Salmonella; Salmonella enterica; transposons
01 Pubblicazione su rivista::01a Articolo in rivista
Plasmid-mediated antimicrobial resistance in Salmonella enterica / Carattoli, A.. - In: CURRENT ISSUES IN MOLECULAR BIOLOGY. - ISSN 1467-3037. - 5:4(2003), pp. 113-122.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1284911
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 125
  • ???jsp.display-item.citation.isi??? ND
social impact