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A conjugative IncL/M plasmid (pSEM) conferring resistance to gentamicin, amikacin, kanamycin, sulfonamides, and expanded-spectrum cephalosporins was found in pathogenic strains of Salmonella enterica serotype Typhimurium. Resistance to aminoglycosides was encoded by a sul1-type class 1 integron (In-t3). An extended-spectrum beta-lactamase gene, bla(SHV-5), was identified 3.5 kb downstream of the integrase (intI1) gene of In-t3. Nucleotide sequence analysis of the 5.3-kb bla(SHV-5)-In-t3 region of pSEM highlighted striking similarities with IncL/M plasmids isolated from nosocomial gram-negative pathogens, conferring resistance to expanded-spectrum cephalosporins and aminoglycosides.

Multiple-antibiotic resistance mediated by structurally related IncL/M plasmids carrying an extended-spectrum β-lactamase gene and a class 1 integron / Villa, L; Pezzella, C; Tosini, F; Visca, P; Petrucca, A; Carattoli, A.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 44:10(2000), pp. 2911-2914. [10.1128/AAC.44.10.2911-2914.2000]

Multiple-antibiotic resistance mediated by structurally related IncL/M plasmids carrying an extended-spectrum β-lactamase gene and a class 1 integron

Visca P;Petrucca A;Carattoli A.
2000

Abstract

A conjugative IncL/M plasmid (pSEM) conferring resistance to gentamicin, amikacin, kanamycin, sulfonamides, and expanded-spectrum cephalosporins was found in pathogenic strains of Salmonella enterica serotype Typhimurium. Resistance to aminoglycosides was encoded by a sul1-type class 1 integron (In-t3). An extended-spectrum beta-lactamase gene, bla(SHV-5), was identified 3.5 kb downstream of the integrase (intI1) gene of In-t3. Nucleotide sequence analysis of the 5.3-kb bla(SHV-5)-In-t3 region of pSEM highlighted striking similarities with IncL/M plasmids isolated from nosocomial gram-negative pathogens, conferring resistance to expanded-spectrum cephalosporins and aminoglycosides.
2000
amikacin; aminoglycoside antibiotic agent; antibiotic agent; aztreonam; beta lactamase; cefamandole; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; cephalosporin derivative; gentamicin; imipenem; kanamycin; spectinomycin; streptomycin; sulfonamide; trimethoprim, antibiotic resistance; article; bacterial infection; Gram negative infection; hospital infection; multidrug resistance; nonhuman; nucleotide sequence; polymerase chain reaction; priority journal; Salmonella enterica, Antibiotics; Antibiotics, Aminoglycoside; beta-Lactamases; Cephalosporin Resistance; Chromosome Mapping; Drug Resistance, Multiple; Electrophoresis, Agar Gel; Integrins; Plasmids; Salmonella enterica; Support, Non-U.S. Gov't
01 Pubblicazione su rivista::01a Articolo in rivista
Multiple-antibiotic resistance mediated by structurally related IncL/M plasmids carrying an extended-spectrum β-lactamase gene and a class 1 integron / Villa, L; Pezzella, C; Tosini, F; Visca, P; Petrucca, A; Carattoli, A.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 44:10(2000), pp. 2911-2914. [10.1128/AAC.44.10.2911-2914.2000]
01a Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1284840
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