Kidney transplant is the treatment of choice for end-stage chronic kidney disease. Kidneys generate 1,25-dihydroxyvitamin D (calcitriol) from 25-hydroxyvitamin D (calcidiol) for circulation in the blood to regulate calcium levels. Transplant patients with low calcidiol levels have an increased risk of metabolic and endocrine problems, cardiovascular disease, type 2 diabetes mellitus, poor graft survival, bone disorders, cancer, and mortality rate. The recommended calcidiol level after transplant is at least 30 ng/mL (75 nmol/L), which could require 1000–3000 IU/d vitamin D3 to achieve. Vitamin D3 supplementation studies have found improved endothelial function and acute rejection episodes. However, since kidney function may still be impaired, raising calcidiol levels may not lead to normal calcitriol levels. Thus, supplementation with calcitriol or an analog, alfacalcidiol, is often employed. Some beneficial effects found include possible improved bone health and reduced risk of chronic allograft nephropathy and cancer.

Current evidence on vitamin D deficiency and kidney transplant: What’s new? / Sarno, G.; Nappi, R.; Altieri, B.; Tirabassi, G.; Muscogiuri, E.; Salvio, G.; Paschou, S. A.; Ferrara, A.; Russo, E.; Vicedomini, D.; Vincenzo, C.; Vryonidou, A.; Della Casa, S.; Balercia, G.; Orio, F.; De Rosa, P.. - In: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. - ISSN 1389-9155. - 18:3(2017), pp. 323-334. [10.1007/s11154-017-9418-z]

Current evidence on vitamin D deficiency and kidney transplant: What’s new?

TIRABASSI PASCUCCI, GABRIELE GIUSEPPE;MUSCOGIURI, EMANUELE;DELLA CASA, STEFANO;
2017

Abstract

Kidney transplant is the treatment of choice for end-stage chronic kidney disease. Kidneys generate 1,25-dihydroxyvitamin D (calcitriol) from 25-hydroxyvitamin D (calcidiol) for circulation in the blood to regulate calcium levels. Transplant patients with low calcidiol levels have an increased risk of metabolic and endocrine problems, cardiovascular disease, type 2 diabetes mellitus, poor graft survival, bone disorders, cancer, and mortality rate. The recommended calcidiol level after transplant is at least 30 ng/mL (75 nmol/L), which could require 1000–3000 IU/d vitamin D3 to achieve. Vitamin D3 supplementation studies have found improved endothelial function and acute rejection episodes. However, since kidney function may still be impaired, raising calcidiol levels may not lead to normal calcitriol levels. Thus, supplementation with calcitriol or an analog, alfacalcidiol, is often employed. Some beneficial effects found include possible improved bone health and reduced risk of chronic allograft nephropathy and cancer.
2017
Bone mineral density; Cardiovascular disease; Kidney graft survival; Kidney transplantation; Malignancies; Vitamin D; Calcitriol; Dietary Supplements; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantation; Vitamin D; Vitamin D Deficiency
01 Pubblicazione su rivista::01a Articolo in rivista
Current evidence on vitamin D deficiency and kidney transplant: What’s new? / Sarno, G.; Nappi, R.; Altieri, B.; Tirabassi, G.; Muscogiuri, E.; Salvio, G.; Paschou, S. A.; Ferrara, A.; Russo, E.; Vicedomini, D.; Vincenzo, C.; Vryonidou, A.; Della Casa, S.; Balercia, G.; Orio, F.; De Rosa, P.. - In: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. - ISSN 1389-9155. - 18:3(2017), pp. 323-334. [10.1007/s11154-017-9418-z]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1284379
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