The gene encoding the carbapenemase OXA-181 (an OXA-48 variant) was identified from a Citrobacter freundii isolate coproducing NDM-1. The whole sequence of plasmid pT-OXA-181 bearing the blaOXA-181 gene was determined and revealed a 84-kb mobilizable but non-self-conjugative IncT-type plasmid. It totally differs from the 7.6-kb ColE-type and bla OXA-181-bearing plasmid recently identified in a Klebsiella pneumoniae isolate. However, in both plasmids, insertion sequence ISEcp1 might have played a role in acquisition of the blaOXA-181 gene. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Complete sequence of the IncT-type plasmid pT-OXA-181 carrying the bla OXA-181 carbapenemase gene from Citrobacter freundii / Villa, L; Carattoli, A; Nordmann, P; Carta, C; Poirel, L.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 57:4(2013), pp. 1965-1967. [10.1128/AAC.01297-12]
Complete sequence of the IncT-type plasmid pT-OXA-181 carrying the bla OXA-181 carbapenemase gene from Citrobacter freundii
Carattoli A;
2013
Abstract
The gene encoding the carbapenemase OXA-181 (an OXA-48 variant) was identified from a Citrobacter freundii isolate coproducing NDM-1. The whole sequence of plasmid pT-OXA-181 bearing the blaOXA-181 gene was determined and revealed a 84-kb mobilizable but non-self-conjugative IncT-type plasmid. It totally differs from the 7.6-kb ColE-type and bla OXA-181-bearing plasmid recently identified in a Klebsiella pneumoniae isolate. However, in both plasmids, insertion sequence ISEcp1 might have played a role in acquisition of the blaOXA-181 gene. Copyright © 2013, American Society for Microbiology. All Rights Reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
