Extensively drug-resistant (XDR) Klebsiella pneumoniae isolates usually carry a single carbapenemase (e.g. KPC, NDM, OXA-48-like). Here we describe an XDR K. pneumoniae of sequence type 101 that was detected in the screening rectal swab of a patient transferred from the intensive care unit of a hospital located in Belgrade (Serbia) to Bern University Hospital (Switzerland). The isolate was resistant to all antibiotics with the exception of colistin [minimum inhibitory concentration] (MIC ≤ 0.125 μg/mL), tigecycline (MIC = 0.5 μg/mL) and fosfomycin (MIC = 2 μg/mL). The isolate co-possessed class B (NDM-1) and class D (OXA-48) carbapenemases, class A extended-spectrum β-lactamase (CTX-M-15), class C cephalosporinase (CMY-16), ArmA 16S rRNA methyltransferase, substitutions in GyrA and ParC, loss of OmpK35 porin, as well as other genes conferring resistance to quinolones (qnrA), tetracyclines [tet(A)], sulfonamides (sul1, sul2), trimethoprim (dfrA12, dfrA14), rifampicin (arr-1), chloramphenicol (cmlA1, floR) and streptomycin (aadA1). The patient was placed under contact isolation precautions preventing the spread of this nearly untreatable pathogen. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland / Seiffert, S. N.; Marschall, J; Perreten, V; Carattoli, A; Furrer, H; Endimiani, A.. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 44:3(2014), pp. 260-262. [10.1016/j.ijantimicag.2014.05.008]

Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland

Carattoli A;
2014

Abstract

Extensively drug-resistant (XDR) Klebsiella pneumoniae isolates usually carry a single carbapenemase (e.g. KPC, NDM, OXA-48-like). Here we describe an XDR K. pneumoniae of sequence type 101 that was detected in the screening rectal swab of a patient transferred from the intensive care unit of a hospital located in Belgrade (Serbia) to Bern University Hospital (Switzerland). The isolate was resistant to all antibiotics with the exception of colistin [minimum inhibitory concentration] (MIC ≤ 0.125 μg/mL), tigecycline (MIC = 0.5 μg/mL) and fosfomycin (MIC = 2 μg/mL). The isolate co-possessed class B (NDM-1) and class D (OXA-48) carbapenemases, class A extended-spectrum β-lactamase (CTX-M-15), class C cephalosporinase (CMY-16), ArmA 16S rRNA methyltransferase, substitutions in GyrA and ParC, loss of OmpK35 porin, as well as other genes conferring resistance to quinolones (qnrA), tetracyclines [tet(A)], sulfonamides (sul1, sul2), trimethoprim (dfrA12, dfrA14), rifampicin (arr-1), chloramphenicol (cmlA1, floR) and streptomycin (aadA1). The patient was placed under contact isolation precautions preventing the spread of this nearly untreatable pathogen. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
2014
antiinfective agent; ArmA protein, E coli; bacterial DNA; bacterial protein; beta lactamase; Escherichia coli protein; methyltransferase; Qnr protein, Klebsiella pneumoniae, biosynthesis; case report; chemistry; cluster analysis; drug effects; feces; genetics; heterozygote; human; intensive care unit; isolation and purification; Klebsiella infection; Klebsiella pneumoniae; male; microbial sensitivity test; microbiology; middle aged; multidrug resistance; Switzerland, Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carrier State; Cluster Analysis; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Escherichia coli Proteins; Feces; Humans; Intensive Care Units; Klebsiella Infections; Klebsiella pneumoniae; Male; Methyltransferases; Microbial Sensitivity Tests; Middle Aged; Switzerland
01 Pubblicazione su rivista::01a Articolo in rivista
Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland / Seiffert, S. N.; Marschall, J; Perreten, V; Carattoli, A; Furrer, H; Endimiani, A.. - In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. - ISSN 0924-8579. - 44:3(2014), pp. 260-262. [10.1016/j.ijantimicag.2014.05.008]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1284321
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