A carbapenem-resistant Enterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes, blaNDM-1 and blaKPC-2, on separate IncF plasmids. The coexistence of blaNDM-1 and blaKPC-2 conferred slightly higher-level carbapenem resistance compared with that of blaNDM-1 or blaKPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Characterization of an Enterobacter cloacae strain producing both KPC and NDM carbapenemases by whole-genome sequencing / Wu, W; Feng, Y; Carattoli, A; Zong, Z.. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 59:10(2015), pp. 6625-6628. [10.1128/AAC.01275-15]
Characterization of an Enterobacter cloacae strain producing both KPC and NDM carbapenemases by whole-genome sequencing
Carattoli A;
2015
Abstract
A carbapenem-resistant Enterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes, blaNDM-1 and blaKPC-2, on separate IncF plasmids. The coexistence of blaNDM-1 and blaKPC-2 conferred slightly higher-level carbapenem resistance compared with that of blaNDM-1 or blaKPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes. Copyright © 2015, American Society for Microbiology. All Rights Reserved.| File | Dimensione | Formato | |
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