The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet volume (MPV) and mean platelet diameter (MPD) with good diagnostic accuracy in this respect. To validate these cut-off values in a different and larger case series of patients, we enrolled 130 subjects with ITP and 113 with IT in six different centres. The platelet count and MPV was each measured by the instrument routinely used in each institution. In some centres, platelet count was also measured by optical microscopy. MPD was evaluated centrally by image analysis of peripheral blood films. The previously identified cut-off value for MPV had 91% specificity in distinguishing ITP from inherited macrothrombocytopenias (mono and biallelic Bernard-Soulier, MYH9-related disease), while its sensitivity was greatly variable depending on the instrument used. With an appropriate instrument, specificity was 83%. The diagnostic accuracy of MPD was lower than that obtained with MPV. We concluded that MPV is a useful parameter for differentiating ITP from IT provided that it is measured by appropriate cell counters. © 2013 John Wiley & Sons Ltd.
Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: A multicentric, real life study / Noris, P.; Klersy, C.; Gresele, P.; Giona, F.; Giordano, Paola; Minuz, P.; Loffredo, G.; Pecci, A.; Melazzini, F.; Civaschi, E.; Mezzasoma, A.; Piedimonte, M.; Semeraro, F.; Veneri, D.; Menna, Filippo; Ciardelli, L.; Balduini, C. L.. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - 162:1(2013), pp. 112-119. [10.1111/bjh.12349]
Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: A multicentric, real life study
Giona F.;GIORDANO, PAOLA;Piedimonte M.;MENNA, FILIPPO;
2013
Abstract
The most frequent forms of inherited thrombocytopenia (IT) are characterized by platelet size abnormalities and it has been suggested that this parameter is useful for their differentiation from immune thrombocytopenia (ITP). Recently, a monocentric study identified cut-off values for mean platelet volume (MPV) and mean platelet diameter (MPD) with good diagnostic accuracy in this respect. To validate these cut-off values in a different and larger case series of patients, we enrolled 130 subjects with ITP and 113 with IT in six different centres. The platelet count and MPV was each measured by the instrument routinely used in each institution. In some centres, platelet count was also measured by optical microscopy. MPD was evaluated centrally by image analysis of peripheral blood films. The previously identified cut-off value for MPV had 91% specificity in distinguishing ITP from inherited macrothrombocytopenias (mono and biallelic Bernard-Soulier, MYH9-related disease), while its sensitivity was greatly variable depending on the instrument used. With an appropriate instrument, specificity was 83%. The diagnostic accuracy of MPD was lower than that obtained with MPV. We concluded that MPV is a useful parameter for differentiating ITP from IT provided that it is measured by appropriate cell counters. © 2013 John Wiley & Sons Ltd.File | Dimensione | Formato | |
---|---|---|---|
Noris_platelet-size_2013.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
163.06 kB
Formato
Adobe PDF
|
163.06 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.