Extracellular proteolytic enzymes of micromycetes belonging to Aspergillus genus have the ability to affect haemostasis proteins as activators (starting procoagulant and anticoagulant processes) or direct fibrinolytics (breaking down clots that had already formed). It was first shown that proteases of some strains are capable to affect proteins of human haemostasis proteins, such as protein C (A. ochraceus L-1, A. flavipes A17), factor X (A. ochraceus L-1, A. flavipes A17), prekallikrein (A. terreus 2). Also new producers of fibrinolytic (A. ochraceus L-1, A. oryzae k1, A. versicolor 1, A. ustus 1, A. fumigatus D1, and A. sydowii 1) and fibrinogenolytic (A. ochraceus L-1) enzymes were founded. Thus, aspergilli produce proteases capable to promote proteolysis of haemostasis proteins or, along with hydrolytic activity, to show the ability to activate proenzymes of haemostasis system transforming them into active forms. It also has been shown that proteases from A. ochraceus have properties similar to properties of activating proteases obtained from venom of the South American copperhead and used in protein C diagnostics. Specific activity of Aspergillus proteinases towards the human haemostasis proteins allows us to consider them perspective substitutes of components in corresponding diagnostic kits and therapeutic substances in prevention and cure thromboembolic diseases.

Micromycetes from the genus Aspergillus as perspective producers of proteases effecting on human haemostasis proteins / Osmolovskiy, Alexander; Zvonareva, Elena; Orekhova, Anastasia; Rukavitsyna, Elizaveta; Bednenko, Daria; Popova, Elizaveta. - In: JOURNAL OF BIOTECHNOLOGY. - ISSN 0168-1656. - 256:S(2017), pp. S94-S94. (Intervento presentato al convegno European Biotechnology Congress tenutosi a Dubrovnik; Croatia) [10.1016/j.jbiotec.2017.06.1123].

Micromycetes from the genus Aspergillus as perspective producers of proteases effecting on human haemostasis proteins

Anastasia Orekhova;
2017

Abstract

Extracellular proteolytic enzymes of micromycetes belonging to Aspergillus genus have the ability to affect haemostasis proteins as activators (starting procoagulant and anticoagulant processes) or direct fibrinolytics (breaking down clots that had already formed). It was first shown that proteases of some strains are capable to affect proteins of human haemostasis proteins, such as protein C (A. ochraceus L-1, A. flavipes A17), factor X (A. ochraceus L-1, A. flavipes A17), prekallikrein (A. terreus 2). Also new producers of fibrinolytic (A. ochraceus L-1, A. oryzae k1, A. versicolor 1, A. ustus 1, A. fumigatus D1, and A. sydowii 1) and fibrinogenolytic (A. ochraceus L-1) enzymes were founded. Thus, aspergilli produce proteases capable to promote proteolysis of haemostasis proteins or, along with hydrolytic activity, to show the ability to activate proenzymes of haemostasis system transforming them into active forms. It also has been shown that proteases from A. ochraceus have properties similar to properties of activating proteases obtained from venom of the South American copperhead and used in protein C diagnostics. Specific activity of Aspergillus proteinases towards the human haemostasis proteins allows us to consider them perspective substitutes of components in corresponding diagnostic kits and therapeutic substances in prevention and cure thromboembolic diseases.
2017
European Biotechnology Congress
04 Pubblicazione in atti di convegno::04d Abstract in atti di convegno
Micromycetes from the genus Aspergillus as perspective producers of proteases effecting on human haemostasis proteins / Osmolovskiy, Alexander; Zvonareva, Elena; Orekhova, Anastasia; Rukavitsyna, Elizaveta; Bednenko, Daria; Popova, Elizaveta. - In: JOURNAL OF BIOTECHNOLOGY. - ISSN 0168-1656. - 256:S(2017), pp. S94-S94. (Intervento presentato al convegno European Biotechnology Congress tenutosi a Dubrovnik; Croatia) [10.1016/j.jbiotec.2017.06.1123].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1281666
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