Muscle mass has been shown to be a prognostic marker in patients with liver cirrhosis. Transversal psoas muscle thickness normalized by height (TPMT/height) obtained by routine computed tomography is a simple surrogate parameter for sarcopenia. TPMT/height, however, is not sex specific, which might play a role in risk stratification. Its association with acute-on-chronic liver failure (ACLF) has not been established yet. ACLF is associated with systemic inflammatory dysregulation. This study aimed at evaluating the role of sarcopenia in ACLF development of patients with decompensated cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) using sex-specific TPMT/height.
Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt / Praktiknjo, Michael; Clees, Caroline; Pigliacelli, Alessandra; Fischer, Stefan; Jansen, Christian; Lehmann, Jennifer; Pohlmann, Alessandra; Lattanzi, Barbara; Krabbe, Viktoria Katharina; Strassburg, Christian P; Arroyo, Vicente; Merli, Manuela; Meyer, Carsten; Trebicka, Jonel. - In: CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY. - ISSN 2155-384X. - 10:4(2019), p. e00025. [10.14309/ctg.0000000000000025]
Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt
Pigliacelli, AlessandraInvestigation
;Lattanzi, BarbaraInvestigation
;Merli, ManuelaWriting – Review & Editing
;
2019
Abstract
Muscle mass has been shown to be a prognostic marker in patients with liver cirrhosis. Transversal psoas muscle thickness normalized by height (TPMT/height) obtained by routine computed tomography is a simple surrogate parameter for sarcopenia. TPMT/height, however, is not sex specific, which might play a role in risk stratification. Its association with acute-on-chronic liver failure (ACLF) has not been established yet. ACLF is associated with systemic inflammatory dysregulation. This study aimed at evaluating the role of sarcopenia in ACLF development of patients with decompensated cirrhosis receiving transjugular intrahepatic portosystemic shunt (TIPS) using sex-specific TPMT/height.| File | Dimensione | Formato | |
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