The antibacterial activity of cefotetan compared with that of ampicillin, cephaloridine, cefotaxime, cefuroxime and cefoxitin was determined against 109 recent clinical isolates of Gram positive and Gram-negative bacteria .The antibacterial activity was evaluated by the MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) in agar. Moreover stability of the quoted B-lactam agents to hydrolysis by some B-lactamases of various origin was compared. Antibacterial activity of cefotetan was shown to be bactericidal, with a high activity against Escherichia coli, Enterobacter and Proteus spp.furthermore, cefotetan was shown to be highly stable to beta-lactamases of various origin.
In vitro activity of cefotetan compared with other B-lactam agents / Scazzocchio, Francesca; Repetto, A; Mari, P; Renzini, Giulio. - In: CHEMIOTERAPIA. - ISSN 0392-906X. - 2(4):(1983), pp. 237-240.
In vitro activity of cefotetan compared with other B-lactam agents
SCAZZOCCHIO, Francesca;RENZINI, Giulio
1983
Abstract
The antibacterial activity of cefotetan compared with that of ampicillin, cephaloridine, cefotaxime, cefuroxime and cefoxitin was determined against 109 recent clinical isolates of Gram positive and Gram-negative bacteria .The antibacterial activity was evaluated by the MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) in agar. Moreover stability of the quoted B-lactam agents to hydrolysis by some B-lactamases of various origin was compared. Antibacterial activity of cefotetan was shown to be bactericidal, with a high activity against Escherichia coli, Enterobacter and Proteus spp.furthermore, cefotetan was shown to be highly stable to beta-lactamases of various origin.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
