Vitamin D status has been previously associated with a wide range of acute and chronic diseases. The nervous system express vitamin D receptors and thus vitamin D may be involved in mental health. Poor data exist about the correlation between vitamin D and anxiety levels.Our aim was to investigate the association of vitamin D status with anxiety severity. A group of 177 postmenopausal women (mean age 65.5±8.22 yr.) referring to an outpatients clinic for the prevention of osteoporosis were evaluated. Severity of perceived anxiety symptoms was measured by the Hamilton Anxiety rating scale (HAMA). Depression levels were also evaluated using the Beck Depression Inventory-second edition scale (BDI-II). 25(OH)D serum levels, indicative of vitamin D status, were detected by high-performance liquid chromatography. 25(OH)D levels were significantly related HAMA-score (r=-0.15, p=0.04); particularly a deep association was observed between 25(OH)D levels and somatic symptoms (r=-0.195, p=0.009). HAMA score was associated with BDI-II score (r=0.487, p=<0.001); HAMA psychic symptom score was also related with age and time since menopause (r=0.149, p=0.039 and r=0.222, p=0.003, respectively). At a multiple regression analysis, after correcting for age and depression levels, 25(OH)D was predictive of HAMA score (β =-0,05961, p= 0.02, SE=-2.206), but the strength of association was lost further correcting for time since menopause. In conclusion, in a setting of postmenopausal women, we observed a significant association between anxiety levels and serum 25(OH)D concentrations irrespective of age and depression levels.

Vitamin D status is associated with anxiety levels in postmenopausal women evaluated for osteoporosis / Martino, Gabriella; Catalano, Antonino; Bellone, Federica; Sardella, Alberto; Lasco, Carmen; Caprì, Tindara; Langher, Viviana; Caputo, Andrea; Angela Fabio, Rosa; Morabito, Nunziata. - In: MEDITERRANEAN JOURNAL OF CLINICAL PSYCHOLOGY. - ISSN 2282-1619. - 6:1(2018), pp. 1-16. [10.6092/2282-1619/2018.6.1740]

Vitamin D status is associated with anxiety levels in postmenopausal women evaluated for osteoporosis

Viviana Langher;Andrea Caputo;
2018

Abstract

Vitamin D status has been previously associated with a wide range of acute and chronic diseases. The nervous system express vitamin D receptors and thus vitamin D may be involved in mental health. Poor data exist about the correlation between vitamin D and anxiety levels.Our aim was to investigate the association of vitamin D status with anxiety severity. A group of 177 postmenopausal women (mean age 65.5±8.22 yr.) referring to an outpatients clinic for the prevention of osteoporosis were evaluated. Severity of perceived anxiety symptoms was measured by the Hamilton Anxiety rating scale (HAMA). Depression levels were also evaluated using the Beck Depression Inventory-second edition scale (BDI-II). 25(OH)D serum levels, indicative of vitamin D status, were detected by high-performance liquid chromatography. 25(OH)D levels were significantly related HAMA-score (r=-0.15, p=0.04); particularly a deep association was observed between 25(OH)D levels and somatic symptoms (r=-0.195, p=0.009). HAMA score was associated with BDI-II score (r=0.487, p=<0.001); HAMA psychic symptom score was also related with age and time since menopause (r=0.149, p=0.039 and r=0.222, p=0.003, respectively). At a multiple regression analysis, after correcting for age and depression levels, 25(OH)D was predictive of HAMA score (β =-0,05961, p= 0.02, SE=-2.206), but the strength of association was lost further correcting for time since menopause. In conclusion, in a setting of postmenopausal women, we observed a significant association between anxiety levels and serum 25(OH)D concentrations irrespective of age and depression levels.
2018
Vitamin D; anxiety; depression; postmenopausal women; osteoporosis
01 Pubblicazione su rivista::01a Articolo in rivista
Vitamin D status is associated with anxiety levels in postmenopausal women evaluated for osteoporosis / Martino, Gabriella; Catalano, Antonino; Bellone, Federica; Sardella, Alberto; Lasco, Carmen; Caprì, Tindara; Langher, Viviana; Caputo, Andrea; Angela Fabio, Rosa; Morabito, Nunziata. - In: MEDITERRANEAN JOURNAL OF CLINICAL PSYCHOLOGY. - ISSN 2282-1619. - 6:1(2018), pp. 1-16. [10.6092/2282-1619/2018.6.1740]
File allegati a questo prodotto
File Dimensione Formato  
martino_vitamin_2018.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 186.38 kB
Formato Adobe PDF
186.38 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1278612
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 22
social impact