Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidis biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.

Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis / Ricciardelli, A; Casillo, A; Papa, R; Monti, Dm; Imbimbo, P; Vrenna, G; Artini, M; Selan, L; Corsaro, Mm; Tutino, Ml; Parrilli, E.. - In: BIOFOULING. - ISSN 0892-7014. - 34:10(2018), pp. 1110-1120. [10.1080/08927014.2018.1544246]

Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis

Papa R;Vrenna G;Artini M;Selan L;
2018

Abstract

Staphylococcus epidermidis, a harmless human skin colonizer, is a significant nosocomial pathogen in predisposed hosts because of its capability to form a biofilm on indwelling medical devices. In a recent paper, the purification and identification of the pentadecanal produced by the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125, able to impair S. epidermidis biofilm formation, were reported. Here the authors report on the chemical synthesis of pentadecanal derivatives, their anti-biofilm activity on S. epidermidis, and their action in combination with antibiotics. The results clearly indicate that the pentadecanal derivatives were able to prevent, to a different extent, biofilm formation and that pentadecanoic acid positively modulated the antimicrobial activity of the vancomycin. The cytotoxicity of these new anti-biofilm molecules was tested on two different immortalized eukaryotic cell lines in view of their potential applications.
Anti-biofilm; pentadecanal; pseudoalteromonas haloplanktis tac125; vancomycin; pentadecanoic acid; pentadecanoic acid methyl ester; 1,1-dimethoxypentadecane
01 Pubblicazione su rivista::01a Articolo in rivista
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis / Ricciardelli, A; Casillo, A; Papa, R; Monti, Dm; Imbimbo, P; Vrenna, G; Artini, M; Selan, L; Corsaro, Mm; Tutino, Ml; Parrilli, E.. - In: BIOFOULING. - ISSN 0892-7014. - 34:10(2018), pp. 1110-1120. [10.1080/08927014.2018.1544246]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1278161
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