It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between their etiopathogenesis and the properties of molecules involved. Are there specific features that explain the exclusive association of proteins with either cancer or neurodegeneration? We performed a large-scale analysis of physico-chemical properties to understand what characteristics differentiate classes of diseases. We found that structural disorder significantly distinguishes proteins up-regulated in neurodegenerative diseases from those linked to cancer. We also observed high correlation between structural disorder and age of onset in Frontotemporal Dementia, Parkinson's and Alzheimer's diseases, which strongly supports the role of protein unfolding in neurodegenerative processes.

Neurodegeneration and cancer: where the disorder prevails / Klus, Petr; Cirillo, Davide; Botta Orfila, Teresa; Gaetano Tartaglia, Gian. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 5:1(2015), pp. 1-7. [10.1038/srep15390]

Neurodegeneration and cancer: where the disorder prevails

Gaetano Tartaglia, Gian
2015

Abstract

It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between their etiopathogenesis and the properties of molecules involved. Are there specific features that explain the exclusive association of proteins with either cancer or neurodegeneration? We performed a large-scale analysis of physico-chemical properties to understand what characteristics differentiate classes of diseases. We found that structural disorder significantly distinguishes proteins up-regulated in neurodegenerative diseases from those linked to cancer. We also observed high correlation between structural disorder and age of onset in Frontotemporal Dementia, Parkinson's and Alzheimer's diseases, which strongly supports the role of protein unfolding in neurodegenerative processes.
2015
Humans; Neoplasms; Neurodegenerative Diseases; Multidisciplinary
01 Pubblicazione su rivista::01a Articolo in rivista
Neurodegeneration and cancer: where the disorder prevails / Klus, Petr; Cirillo, Davide; Botta Orfila, Teresa; Gaetano Tartaglia, Gian. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 5:1(2015), pp. 1-7. [10.1038/srep15390]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1277760
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