BACKGROUND:The information on the geographical characteristics of chronic liver diseases (CLD) in Italy is out-dated. AIM:To provide up-dated information on the geographical pattern of patients with CLD born in Italy. METHODS:Patients with CLD were enrolled in two national surveys performed in 2001 and 2014, which prospectively recruited subjects aged ≥18 years referring to Italian liver units located throughout the country that apply a similar clinical approach and analytical methods. RESULTS:The total number of patients enrolled was 11,676. Alcohol-related CLD was more frequently observed in northern/central areas (25.0% vs. 20.7%, p < .001), while HBV-related (15.4% vs. 13.3%, p = .02) and HCV-related (71.2% vs. 67.1%, p < .001) CLD prevailed in southern areas/main islands (Sicily and Sardinia). These differences were stable over time. Liver cirrhosis without HCC was diagnosed more frequently in southern area/islands than in northern/central areas (23.7% vs. 18.8%, p < .01). Moreover, an increased proportion over time of patients with cirrhosis without HCC was observed both in northern/central areas (17.3% vs. 27.4%, p < .01) and in southern area/islands (22.6% vs. 27.9%, p < .01). CONCLUSIONS:These up-dated findings show different geographical patterns of CLD in Italy, reflecting different behavioural habits and socio-economic conditions across the country. They may be useful to apply more adequate preventive measures and to allocate economic resources.
Geographical pattern of chronic liver diseases in Italy: Results from two pooled national surveys / Stroffolini, Tommaso; Sagnelli, Evangelista; Sagnelli, Caterina; Smedile, Antonina; Morisco, Filomena; Coppola, Nicola; Furlan, Caterina; Almasio, Piero Luigi. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 61:(2019), pp. 40-43. [10.1016/j.ejim.2018.10.015]
Geographical pattern of chronic liver diseases in Italy: Results from two pooled national surveys
Furlan, CaterinaPenultimo
;
2019
Abstract
BACKGROUND:The information on the geographical characteristics of chronic liver diseases (CLD) in Italy is out-dated. AIM:To provide up-dated information on the geographical pattern of patients with CLD born in Italy. METHODS:Patients with CLD were enrolled in two national surveys performed in 2001 and 2014, which prospectively recruited subjects aged ≥18 years referring to Italian liver units located throughout the country that apply a similar clinical approach and analytical methods. RESULTS:The total number of patients enrolled was 11,676. Alcohol-related CLD was more frequently observed in northern/central areas (25.0% vs. 20.7%, p < .001), while HBV-related (15.4% vs. 13.3%, p = .02) and HCV-related (71.2% vs. 67.1%, p < .001) CLD prevailed in southern areas/main islands (Sicily and Sardinia). These differences were stable over time. Liver cirrhosis without HCC was diagnosed more frequently in southern area/islands than in northern/central areas (23.7% vs. 18.8%, p < .01). Moreover, an increased proportion over time of patients with cirrhosis without HCC was observed both in northern/central areas (17.3% vs. 27.4%, p < .01) and in southern area/islands (22.6% vs. 27.9%, p < .01). CONCLUSIONS:These up-dated findings show different geographical patterns of CLD in Italy, reflecting different behavioural habits and socio-economic conditions across the country. They may be useful to apply more adequate preventive measures and to allocate economic resources.File | Dimensione | Formato | |
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