Myocardial hypertrophy is a response of cardiac muscle to altered conditions of haemodynamic overload caused by a large number of physiological and pathological conditions. Traditionally, it has been considered a beneficial mechanism. However, sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. Actually, many researchers are trying to understand whether left ventricular hypertrophy is a ‘good’ mechanism to stimulate or a ‘bad’ process to prevent. In this review we investigate the most common biochemical signaling pathways involved in the hypertrophic response to identify the precise role, either ‘adaptive’ or ‘maladaptive’, of each molecular pathway. Delinealing intracellular signaling pathways involved in the different aspects of cardiac hypertrophy will permit future improvements in the signaling that controls beneficial growth.

Adaptative and maladaptative hypertrophic pathways: points of convergence and divergence / Selvetella, G.; Hirsch, E.; Notte, A.; Tarone, G.; Lembo, Giuseppe. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - STAMPA. - 63:3(2004), pp. 373-380. [10.1016/j.cardiores.2004.04.031]

Adaptative and maladaptative hypertrophic pathways: points of convergence and divergence.

LEMBO, Giuseppe
2004

Abstract

Myocardial hypertrophy is a response of cardiac muscle to altered conditions of haemodynamic overload caused by a large number of physiological and pathological conditions. Traditionally, it has been considered a beneficial mechanism. However, sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. Actually, many researchers are trying to understand whether left ventricular hypertrophy is a ‘good’ mechanism to stimulate or a ‘bad’ process to prevent. In this review we investigate the most common biochemical signaling pathways involved in the hypertrophic response to identify the precise role, either ‘adaptive’ or ‘maladaptive’, of each molecular pathway. Delinealing intracellular signaling pathways involved in the different aspects of cardiac hypertrophy will permit future improvements in the signaling that controls beneficial growth.
2004
ipertrofia cardiaca; vie di segnalazione; topi geneticamente modificati
01 Pubblicazione su rivista::01a Articolo in rivista
Adaptative and maladaptative hypertrophic pathways: points of convergence and divergence / Selvetella, G.; Hirsch, E.; Notte, A.; Tarone, G.; Lembo, Giuseppe. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - STAMPA. - 63:3(2004), pp. 373-380. [10.1016/j.cardiores.2004.04.031]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/127637
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