PURPOSE OF THE REVIEW: To summarize available evidence regarding lipid-lowering interventions for the prevention of cardiovascular disease in patients with diabetes. RECENT FINDINGS: Statins and non-statin therapies that act through upregulation of LDL receptor expression are associated with similar cardiovascular risk reduction per decrease in LDL cholesterol. In subjects with diabetes, with or without established cardiovascular disease, each 39 mg/dl reduction in LDL cholesterol observed with statins is associated with a 21% relative reduction in the risk of major coronary events at 5 years. Statins remain the first-line lipid-lowering agents for the management of dyslipidemia in individuals with diabetes; however, the addition of non-statin therapies to lower LDL cholesterol, such as ezetimibe and PCSK-9 inhibitors, to maximally tolerated statin therapy is recommended in patients with atherosclerotic cardiovascular disease and baseline LDL cholesterol over 70 mg/dl. Recent data support even lower LDL cholesterol targets (< 55 mg/dl) to further reduce the risk of cardiovascular events especially in subjects with diabetes and documented cardiovascular disease.

Comparison of lipid-lowering medications and risk for cardiovascular disease in diabetes / Cavallari, Ilaria; Delli Veneri, Alessia; Maddaloni, Ernesto; Melfi, Rosetta; Patti, Giuseppe; Napoli, Nicola; Pozzilli, Paolo; Di Sciascio, Germano. - In: CURRENT DIABETES REPORT. - ISSN 1534-4827. - 18:12(2018). [10.1007/s11892-018-1117-y]

Comparison of lipid-lowering medications and risk for cardiovascular disease in diabetes

Maddaloni, Ernesto;
2018

Abstract

PURPOSE OF THE REVIEW: To summarize available evidence regarding lipid-lowering interventions for the prevention of cardiovascular disease in patients with diabetes. RECENT FINDINGS: Statins and non-statin therapies that act through upregulation of LDL receptor expression are associated with similar cardiovascular risk reduction per decrease in LDL cholesterol. In subjects with diabetes, with or without established cardiovascular disease, each 39 mg/dl reduction in LDL cholesterol observed with statins is associated with a 21% relative reduction in the risk of major coronary events at 5 years. Statins remain the first-line lipid-lowering agents for the management of dyslipidemia in individuals with diabetes; however, the addition of non-statin therapies to lower LDL cholesterol, such as ezetimibe and PCSK-9 inhibitors, to maximally tolerated statin therapy is recommended in patients with atherosclerotic cardiovascular disease and baseline LDL cholesterol over 70 mg/dl. Recent data support even lower LDL cholesterol targets (< 55 mg/dl) to further reduce the risk of cardiovascular events especially in subjects with diabetes and documented cardiovascular disease.
2018
cardiovascular disease; diabetes; lipid-lowering interventions
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Comparison of lipid-lowering medications and risk for cardiovascular disease in diabetes / Cavallari, Ilaria; Delli Veneri, Alessia; Maddaloni, Ernesto; Melfi, Rosetta; Patti, Giuseppe; Napoli, Nicola; Pozzilli, Paolo; Di Sciascio, Germano. - In: CURRENT DIABETES REPORT. - ISSN 1534-4827. - 18:12(2018). [10.1007/s11892-018-1117-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1276339
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