AIM To evaluate the efficacy of 0.1% topical salicylic acid (TSA) to treat iatrogenic chronic blepharoconjunctivitis in patients with primary open angle glaucoma (POAG), treated with topical prostaglandin analogues (TPAs). METHODS Totally 60 patients were randomly distributed into 3 equal size groups, two of which treated with 0.1% TSA (OMKASA®) and 0.1% topical clobetasone butyrate (TCB; VISUCLOBEN®) respectively, and one consisting of untreated controls. The parameters taken into account at baseline (T0) and after 30d (T1) of therapy were: conjunctival hyperemia, lacrimal function tests [Schirmer I test and break up time (BUT)] and intraocular pressure (IOP). RESULTS Conjunctival hyperemia showed a substantial improvement in both treated groups (P<0.001) but not among controls. Similarly, lacrimal function tests displayed an improvement of Schirmer I test in both treated groups (P<0.05) and an extension of BUT only in the group treated with 0.1% TSA (P<0.05). The IOP increase was statistically significant only in those patients treated with 0.1% TCB (P<0.001). CONCLUSION The 0.1% TSA has proved to be an effective anti-inflammatory treatment of blepharoconjunctivitis affecting glaucoma patients on therapy with TPAs, leading to a sizeable decrease of inflammation as well as both quantitative and qualitative improvement of tear film. Furthermore, differently from 0.1% TCB, it does not induce any significant IOP increase.

Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial / LIBRANDO, Aloisa; CARLESIMO, Sandra Cinzia; ALBANESE, GIORGIO; ALBANESE, GIUSEPPE MARIA; MIGLIORINI, Raffaele; PACELLA, Elena. - In: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY. - ISSN 2222-3959. - 11:12(2018), pp. 1936-1940. [10.18240/ijo.2018.12.10]

Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial

Aloisa Librando
Primo
;
Sandra Cinzia Carlesimo
Secondo
;
Giorgio Albanese;Giuseppe Maria Albanese;Raffaele Migliorini
Penultimo
;
Elena Pacella
Ultimo
2018

Abstract

AIM To evaluate the efficacy of 0.1% topical salicylic acid (TSA) to treat iatrogenic chronic blepharoconjunctivitis in patients with primary open angle glaucoma (POAG), treated with topical prostaglandin analogues (TPAs). METHODS Totally 60 patients were randomly distributed into 3 equal size groups, two of which treated with 0.1% TSA (OMKASA®) and 0.1% topical clobetasone butyrate (TCB; VISUCLOBEN®) respectively, and one consisting of untreated controls. The parameters taken into account at baseline (T0) and after 30d (T1) of therapy were: conjunctival hyperemia, lacrimal function tests [Schirmer I test and break up time (BUT)] and intraocular pressure (IOP). RESULTS Conjunctival hyperemia showed a substantial improvement in both treated groups (P<0.001) but not among controls. Similarly, lacrimal function tests displayed an improvement of Schirmer I test in both treated groups (P<0.05) and an extension of BUT only in the group treated with 0.1% TSA (P<0.05). The IOP increase was statistically significant only in those patients treated with 0.1% TCB (P<0.001). CONCLUSION The 0.1% TSA has proved to be an effective anti-inflammatory treatment of blepharoconjunctivitis affecting glaucoma patients on therapy with TPAs, leading to a sizeable decrease of inflammation as well as both quantitative and qualitative improvement of tear film. Furthermore, differently from 0.1% TCB, it does not induce any significant IOP increase.
2018
blepharoconjunctivitis; glaucoma; intraocular pressure; lacrimal function tests; prostaglandin analogues; topical clobetasone butyrate; topical salicylic acid
01 Pubblicazione su rivista::01a Articolo in rivista
Effectiveness of 0.1% topical salicylic acid on blepharoconjunctivitis affecting glaucoma patients treated with topical prostaglandin analogues: a prospective randomized trial / LIBRANDO, Aloisa; CARLESIMO, Sandra Cinzia; ALBANESE, GIORGIO; ALBANESE, GIUSEPPE MARIA; MIGLIORINI, Raffaele; PACELLA, Elena. - In: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY. - ISSN 2222-3959. - 11:12(2018), pp. 1936-1940. [10.18240/ijo.2018.12.10]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1276276
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