Graphene offers promising advantages for biomedical applications. However, adoption of graphene technology in biomedicine also poses important challenges in terms of understanding cell responses, cellular uptake, or the intracellular fate of soluble graphene derivatives. In the biological microenvironment, graphene nanosheets might interact with exposed cellular and subcellular structures, resulting in unexpected regulation of sophisticated biological signaling. More broadly, biomedical devices based on the design of these 2D planar nanostructures for interventions in the central nervous system require an accurate understanding of their interactions with the neuronal milieu. Here, we describe the ability of graphene oxide nanosheets to down-regulate neuronal signaling without affecting cell viability.

Graphene Oxide Nanosheets Reshape Synaptic Function in Cultured Brain Networks / Rauti, Rossana; Lozano, Neus; León, Veronica; Scaini, Denis; Musto, Mattia; Rago, Ilaria; Ulloa Severino, Francesco P; Fabbro, Alessandra; Casalis, Loredana; Vázquez, Ester; Kostarelos, Kostas; Prato, Maurizio; Ballerini, Laura. - In: ACS NANO. - ISSN 1936-0851. - 10:4(2016), pp. 4459-71-4471. [10.1021/acsnano.6b00130]

Graphene Oxide Nanosheets Reshape Synaptic Function in Cultured Brain Networks

Rago, Ilaria;
2016

Abstract

Graphene offers promising advantages for biomedical applications. However, adoption of graphene technology in biomedicine also poses important challenges in terms of understanding cell responses, cellular uptake, or the intracellular fate of soluble graphene derivatives. In the biological microenvironment, graphene nanosheets might interact with exposed cellular and subcellular structures, resulting in unexpected regulation of sophisticated biological signaling. More broadly, biomedical devices based on the design of these 2D planar nanostructures for interventions in the central nervous system require an accurate understanding of their interactions with the neuronal milieu. Here, we describe the ability of graphene oxide nanosheets to down-regulate neuronal signaling without affecting cell viability.
2016
nanotechnology; graphene; patch-clamp; synaptic terminals; exocytosis; FMI-43; microvesicles
01 Pubblicazione su rivista::01a Articolo in rivista
Graphene Oxide Nanosheets Reshape Synaptic Function in Cultured Brain Networks / Rauti, Rossana; Lozano, Neus; León, Veronica; Scaini, Denis; Musto, Mattia; Rago, Ilaria; Ulloa Severino, Francesco P; Fabbro, Alessandra; Casalis, Loredana; Vázquez, Ester; Kostarelos, Kostas; Prato, Maurizio; Ballerini, Laura. - In: ACS NANO. - ISSN 1936-0851. - 10:4(2016), pp. 4459-71-4471. [10.1021/acsnano.6b00130]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1276127
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