Abstract BACKGROUND: It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. OBJECTIVE: In this review, we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. DISCUSSION AND CONCLUSION: While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as an adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.

Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders / Boldrini, Paolo; Fusco, Antonella; Nicoletti, Ferdinando; Badiani, Aldo; Saso, Luciano. - In: CURRENT DRUG TARGETS. - ISSN 1873-5592. - 19:6(2018), pp. 636-650. [10.2174/1389450118666170425153356]

Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders

Boldrini, Paolo
Primo
;
Fusco, Antonella;Nicoletti, Ferdinando;Badiani, Aldo
Penultimo
;
Saso, Luciano
Ultimo
2018

Abstract

Abstract BACKGROUND: It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. OBJECTIVE: In this review, we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. DISCUSSION AND CONCLUSION: While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as an adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.
2018
oxidative stress modulators; anxiety disorders; anxiety models; lipid peroxidation; reactive nitrogen species; reactive oxygen species
01 Pubblicazione su rivista::01a Articolo in rivista
Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders / Boldrini, Paolo; Fusco, Antonella; Nicoletti, Ferdinando; Badiani, Aldo; Saso, Luciano. - In: CURRENT DRUG TARGETS. - ISSN 1873-5592. - 19:6(2018), pp. 636-650. [10.2174/1389450118666170425153356]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1275907
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