Data from 423 human epidermal growth factor receptor 2-negative (HER2-), hormone receptor-positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial responses. The overall response rate (ORR) was 31% (95% confidence interval [CI], 26.6-35.4) and clinical benefit was 52.7% (95% CI, 48-57.5). ORR was negatively affected by prior exposure to everolimus/exemestane (p = 0.002) and favorably influenced by early line-treatment (p < 0.0001). At 6 months, median progression-free survival was 12 months (95% CI, 8-16) and median overall survival was 24 months (95% CI, 17-30). More favorable outcomes were associated with palbociclib in early lines, no visceral metastases and no prior everolimus/exemestane. The main toxicity reported was neutropenia. Our results provide further support to the use of palbociclib with ET in HER2-, HR+ aBC. Differences in outcomes across patients subsets remain largely unexplained.

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: a real-world experience / Pizzuti, Laura; Giordano, Antonio; Michelotti, Andrea; Mazzotta, Marco; Natoli, Clara; Gamucci, Teresa; De Angelis, Claudia; Landucci, Elisabetta; Diodati, Lucrezia; Iezzi, Laura; Mentuccia, Lucia; Fabbri, Agnese; Barba, Maddalena; Sanguineti, Giuseppe; Marchetti, Paolo; Tomao, Silverio; Mariani, Luciano; Paris, Ida; Lorusso, Vito; Vallarelli, Simona; Cassano, Alessandra; Airoldi, Francesca; Orlandi, Armando; Moscetti, Luca; Sergi, Domenico; Sarobba, Maria Giuseppina; Tonini, Giuseppe; Santini, Daniele; Sini, Valentina; Veltri, Enzo; Vaccaro, Angela; Ferrari, Laura; De Tursi, Michele; Tinari, Nicola; Grassadonia, Antonino; Greco, Filippo; Botticelli, Andrea; La Verde, Nicla; Zamagni, Claudio; Rubino, Daniela; Cortesi, Enrico; Magri, Valentina; Pomati, Giulia; Scagnoli, Simone; Capomolla, Elisabetta; Kayal, Ramy; Scinto, Angelo Fedele; Corsi, Domenico; Cazzaniga, Marina; Laudadio, Lucio; Forciniti, Samantha; Mancini, Maria; Carbognin, Luisa; Seminara, Patrizia; Barni, Sandro; Samaritani, Riccardo; Roselli, Mario; Portarena, Ilaria; Russo, Antonio; Ficorella, Corrado; Cannita, Katia; Carpano, Silvia; Pistelli, Mirco; Berardi, Rossana; De Maria, Ruggero; Sperduti, Isabella; Ciliberto, Gennaro; Vici, Patrizia. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - 234:6(2019), pp. 7708-7717. [10.1002/jcp.27832]

Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: a real-world experience

Mentuccia, Lucia;Barba, Maddalena
;
Marchetti, Paolo;Tomao, Silverio;Sergi, Domenico;Santini, Daniele;Sini, Valentina;Ferrari, Laura;Botticelli, Andrea;Cortesi, Enrico;Magri, Valentina;Pomati, Giulia;Scagnoli, Simone;Seminara, Patrizia;
2019

Abstract

Data from 423 human epidermal growth factor receptor 2-negative (HER2-), hormone receptor-positive (HR+) advanced breast cancer (aBC) patients treated with palbociclib and endocrine therapy (ET) were provided by 35 Italian cancer centers and analyzed for treatment outcomes. Overall, 158 patients were treated in first line and 265 in second/later lines. We observed 19 complete responses and 112 partial responses. The overall response rate (ORR) was 31% (95% confidence interval [CI], 26.6-35.4) and clinical benefit was 52.7% (95% CI, 48-57.5). ORR was negatively affected by prior exposure to everolimus/exemestane (p = 0.002) and favorably influenced by early line-treatment (p < 0.0001). At 6 months, median progression-free survival was 12 months (95% CI, 8-16) and median overall survival was 24 months (95% CI, 17-30). More favorable outcomes were associated with palbociclib in early lines, no visceral metastases and no prior everolimus/exemestane. The main toxicity reported was neutropenia. Our results provide further support to the use of palbociclib with ET in HER2-, HR+ aBC. Differences in outcomes across patients subsets remain largely unexplained.
advanced breast cancer; hormonal therapy; endocrine resistance; palbociclib; real-world setting
01 Pubblicazione su rivista::01a Articolo in rivista
Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: a real-world experience / Pizzuti, Laura; Giordano, Antonio; Michelotti, Andrea; Mazzotta, Marco; Natoli, Clara; Gamucci, Teresa; De Angelis, Claudia; Landucci, Elisabetta; Diodati, Lucrezia; Iezzi, Laura; Mentuccia, Lucia; Fabbri, Agnese; Barba, Maddalena; Sanguineti, Giuseppe; Marchetti, Paolo; Tomao, Silverio; Mariani, Luciano; Paris, Ida; Lorusso, Vito; Vallarelli, Simona; Cassano, Alessandra; Airoldi, Francesca; Orlandi, Armando; Moscetti, Luca; Sergi, Domenico; Sarobba, Maria Giuseppina; Tonini, Giuseppe; Santini, Daniele; Sini, Valentina; Veltri, Enzo; Vaccaro, Angela; Ferrari, Laura; De Tursi, Michele; Tinari, Nicola; Grassadonia, Antonino; Greco, Filippo; Botticelli, Andrea; La Verde, Nicla; Zamagni, Claudio; Rubino, Daniela; Cortesi, Enrico; Magri, Valentina; Pomati, Giulia; Scagnoli, Simone; Capomolla, Elisabetta; Kayal, Ramy; Scinto, Angelo Fedele; Corsi, Domenico; Cazzaniga, Marina; Laudadio, Lucio; Forciniti, Samantha; Mancini, Maria; Carbognin, Luisa; Seminara, Patrizia; Barni, Sandro; Samaritani, Riccardo; Roselli, Mario; Portarena, Ilaria; Russo, Antonio; Ficorella, Corrado; Cannita, Katia; Carpano, Silvia; Pistelli, Mirco; Berardi, Rossana; De Maria, Ruggero; Sperduti, Isabella; Ciliberto, Gennaro; Vici, Patrizia. - In: JOURNAL OF CELLULAR PHYSIOLOGY. - ISSN 0021-9541. - 234:6(2019), pp. 7708-7717. [10.1002/jcp.27832]
File allegati a questo prodotto
File Dimensione Formato  
Pizzuti_Palpociclib_2018.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 657.17 kB
Formato Adobe PDF
657.17 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1275290
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 14
social impact