PURPOSE: To analyze the impact of adding computed tomographic (CT) imaging of the chest on the clinical effectiveness and cost-effectiveness of CT colonography to determine whether performing CT colonography and whole-body CT is a more clinically and cost-effective strategy than CT colonography alone when screening average-risk subjects. MATERIALS AND METHODS: A Markov model simulated the occurrence of colorectal neoplasia, extracolonic abominal-pelvic malignancy, lung cancer, coronary artery disease (CAD), and abdominal aortic aneurysm (AAA) in a cohort of 100,000 U.S. subjects aged 50 to 100 years. Cost-effectiveness of CT colonography and whole-body CT was compared with that of CT colonography alone; each test was assumed to be repeated every 10 years between ages of 50 and 80 years. RESULTS: Performing CT colonography and whole-body CT was more effective and costly than was CT colonography alone. The addition of chest CT was associated with a 22% increase in efficacy (life-years gained: 14,662 vs 11,990) and with a 48% increase in cost per person ($13,605 vs $9,223). Both strategies were cost effective as compared with no screening, with an incremental cost-effectiveness ratio (ICER) of $17,672 (CT colonography alone) and $44,337 (CT colonography and whole-body CT), respectively, but performing CT colonography and whole-body CT was not a cost-effective option when compared with CT colonography alone (ICER, $164,020). This was mainly a result of the high cost of false-positive follow-up for CAD and to the poor efficacy of lung cancer screening. Expected value of perfect information was $520 per patient. CONCLUSION: The addition of chest CT to CT colonography does not appear to be a cost-effective alternative. Further research is needed before whole-body CT can be recommended in clinical practice.

Impact of Whole-Body CT Screening on the Cost-effectiveness of CT Colonography / C., Hassan; P. J., Pickhardt; Laghi, Andrea; A., Zullo; D. H., Kim; F., Iafrate; L., Di Giulio; S., Morini. - In: RADIOLOGY. - ISSN 0033-8419. - STAMPA. - 251:(2009), pp. 156-165. [10.1148/radiol.2511080590]

Impact of Whole-Body CT Screening on the Cost-effectiveness of CT Colonography

LAGHI, ANDREA;
2009

Abstract

PURPOSE: To analyze the impact of adding computed tomographic (CT) imaging of the chest on the clinical effectiveness and cost-effectiveness of CT colonography to determine whether performing CT colonography and whole-body CT is a more clinically and cost-effective strategy than CT colonography alone when screening average-risk subjects. MATERIALS AND METHODS: A Markov model simulated the occurrence of colorectal neoplasia, extracolonic abominal-pelvic malignancy, lung cancer, coronary artery disease (CAD), and abdominal aortic aneurysm (AAA) in a cohort of 100,000 U.S. subjects aged 50 to 100 years. Cost-effectiveness of CT colonography and whole-body CT was compared with that of CT colonography alone; each test was assumed to be repeated every 10 years between ages of 50 and 80 years. RESULTS: Performing CT colonography and whole-body CT was more effective and costly than was CT colonography alone. The addition of chest CT was associated with a 22% increase in efficacy (life-years gained: 14,662 vs 11,990) and with a 48% increase in cost per person ($13,605 vs $9,223). Both strategies were cost effective as compared with no screening, with an incremental cost-effectiveness ratio (ICER) of $17,672 (CT colonography alone) and $44,337 (CT colonography and whole-body CT), respectively, but performing CT colonography and whole-body CT was not a cost-effective option when compared with CT colonography alone (ICER, $164,020). This was mainly a result of the high cost of false-positive follow-up for CAD and to the poor efficacy of lung cancer screening. Expected value of perfect information was $520 per patient. CONCLUSION: The addition of chest CT to CT colonography does not appear to be a cost-effective alternative. Further research is needed before whole-body CT can be recommended in clinical practice.
2009
01 Pubblicazione su rivista::01a Articolo in rivista
Impact of Whole-Body CT Screening on the Cost-effectiveness of CT Colonography / C., Hassan; P. J., Pickhardt; Laghi, Andrea; A., Zullo; D. H., Kim; F., Iafrate; L., Di Giulio; S., Morini. - In: RADIOLOGY. - ISSN 0033-8419. - STAMPA. - 251:(2009), pp. 156-165. [10.1148/radiol.2511080590]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/127468
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