The in vitro antifungal activity of extracts obtained from 14 medicinal plants of the mongolian flora were investigated by measuring their minimal inhibitory concentration (MIC) against fungi cause of cutaneous diseases such as Candida species, dermatophytes and Malassezia furfur. Among the species examined, Stellaria dichotoma L., Scutellaria scordifolia L. Aquilegia sibirica Fisch. Et Schrenk. and Hyoscyamus niger L. extracts demonstrated antifungal activity against all studied fungi. In particular, S. scordifolia L. methanol extract, obtained at room temperature, showed the best activity against Candida spp., Malassezia furfur and dermatophytes with GMMIC50 values of 22 µg/mL, 64 µg/mL and 32 µg/mL, respectively. The flavones, luteolin and apigenin, identified in S. scordifolia extracts, and rutin identified in S. dichotoma and Hyoscyamus niger L. extracts, could be responsible of the observed antifungal activity.

Antifungal activity of Mongolian medicinal plant extracts / Giordani, Cristiano; Simonetti, Giovanna; Natsagdorj, Damdinsuren; Choijamts, Gotov; Ghirga, Francesca; Calcaterra, Andrea; Quaglio, Deborah; De Angelis, Giulia; Toniolo, Chiara; Pasqua, Gabriella. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 34:4(2020), pp. 449-455. [10.1080/14786419.2019.1610960]

Antifungal activity of Mongolian medicinal plant extracts

Simonetti, Giovanna
Conceptualization
;
Ghirga, Francesca;Calcaterra, Andrea;Quaglio, Deborah;De Angelis, Giulia;Toniolo, Chiara;Pasqua, Gabriella
2020

Abstract

The in vitro antifungal activity of extracts obtained from 14 medicinal plants of the mongolian flora were investigated by measuring their minimal inhibitory concentration (MIC) against fungi cause of cutaneous diseases such as Candida species, dermatophytes and Malassezia furfur. Among the species examined, Stellaria dichotoma L., Scutellaria scordifolia L. Aquilegia sibirica Fisch. Et Schrenk. and Hyoscyamus niger L. extracts demonstrated antifungal activity against all studied fungi. In particular, S. scordifolia L. methanol extract, obtained at room temperature, showed the best activity against Candida spp., Malassezia furfur and dermatophytes with GMMIC50 values of 22 µg/mL, 64 µg/mL and 32 µg/mL, respectively. The flavones, luteolin and apigenin, identified in S. scordifolia extracts, and rutin identified in S. dichotoma and Hyoscyamus niger L. extracts, could be responsible of the observed antifungal activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1273951
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