The development of a periostin-rich microenvironment in areas associated with insult, orchestrating pathways of repair and rebuilding, is documented. Literature lacks information regarding the presence of periostin in the context of rotator cuff tear (RCT). 55 consecutive patients with RCT were enrolled. Immunohistochemical periostin detection was performed on tissue samples excised from tear margins. Our study documented the presence of periostin in the margins of RCT. It is plausible that, when a tear occurs, multiple stimuli, both mechanical and inflammatory, lead to the development of a periostin-rich microenvironment as an attempt to tendon healing.
The attempt of spontaneous repair of rotator cuff tear: the role of periostin / Gumina, Stefano; Leopizzi, Martina; Carnovale, Michele; Porta, Natale; Giannicola, Giuseppe; Villani, Ciro; Candela, Vittorio. - In: JOURNAL OF ORTHOPAEDICS. - ISSN 0972-978X. - 16:5(2019), pp. 400-404. [10.1016/j.jor.2019.04.018]
The attempt of spontaneous repair of rotator cuff tear: the role of periostin
Gumina, Stefano;Leopizzi, Martina;CARNOVALE, MICHELE;Porta, Natale;Giannicola, Giuseppe;Villani, Ciro;Candela, Vittorio
2019
Abstract
The development of a periostin-rich microenvironment in areas associated with insult, orchestrating pathways of repair and rebuilding, is documented. Literature lacks information regarding the presence of periostin in the context of rotator cuff tear (RCT). 55 consecutive patients with RCT were enrolled. Immunohistochemical periostin detection was performed on tissue samples excised from tear margins. Our study documented the presence of periostin in the margins of RCT. It is plausible that, when a tear occurs, multiple stimuli, both mechanical and inflammatory, lead to the development of a periostin-rich microenvironment as an attempt to tendon healing.File | Dimensione | Formato | |
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