Co-soltrim (lidaprim): microbiological evaluation vs.co-trimoxazole

Cosoltrim (CTM) is the generic name suggested for the new combination of sulfametrole (SMT) (3-methoxy-44(4 amino-benzene-sulfonamide)-1,2,5-thiodazoleeee) with trimethoprim (TMP)in the 1:5 ratio (LIDAPRIM Farmades S.p.A. Roma, Italy). We have studied the antibacterial activity in vitro of SMT-CTM and of cotrimoxazole (CTZ) as a standard drug, on 99 strains of Gram-positive and Gram-negative bacteria which have been recently isolated from hospitalized patients.We also have carried out an in vivo study, by comparing the antibacterial activity(PD50) in mice of CMT with that of CTZ: In vitro, the CTM antibacterial activity appears slightly superior to that of CTZ on E. coli , and Propeus spp. and Providencia spp.:The study on the in vivo activity has been carried out by infecting mice with: Proteus mirabilis CH/1, Salmonella parathyphi.ASA12. The bacterial activity seems to be synergic for both application.