SYNTHESIS OF BETA-LACTAM DERIVATIVES OF 1,5-BENZOXAZEPINES AND 1,5-BENZOTHIAZEPINES

Condensed beta-lactam derivatives of 1,5 benzoxazepines (2a-i) and of 1,5 benzothiazepines (2j-r) have been synthesized by the reaction of quino (2,3-b)(1,5) benzoxazepines (1a-c) or the corresponding benzothiazepines (1d-f) with some acyl chlorides in the presence of triethylamine.The formyl chloroacetamido derivatives (4a,b) were instead obtained by treating 1a,d with chloroacetyl chloride in the absence of the base. The mechanism of the reactions is discussed. No antibacterial activity was shown by the title compounds (2a-r) in the test experimental conditions.