Previous studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas rats tested outside the home prefer cocaine to heroin. Here, we investigated whether drug history would influence subsequent drug preference in distinct settings. Based on a theoretical model of drug-setting interaction, we predicted that regardless of drug history rats would prefer heroin at home and cocaine outside the home.

Heroin versus cocaine: opposite choice as a function of context but not of drug history in the rat / De Luca, Maria Teresa; Montanari, Christian; Meringolo, Maria; Contu, Laura; Celentano, Michele; Badiani, Aldo. - In: PSYCHOPHARMACOLOGY. - ISSN 1432-2072. - 236:2(2019), pp. 787-798. [10.1007/s00213-018-5115-1]

Heroin versus cocaine: opposite choice as a function of context but not of drug history in the rat

De Luca, Maria Teresa
Primo
;
Montanari, Christian
Secondo
;
Meringolo, Maria;Contu, Laura;Celentano, Michele
Penultimo
;
Badiani, Aldo
Ultimo
2019

Abstract

Previous studies have shown that rats trained to self-administer heroin and cocaine exhibit opposite preferences, as a function of setting, when tested in a choice paradigm. Rats tested at home prefer heroin to cocaine, whereas rats tested outside the home prefer cocaine to heroin. Here, we investigated whether drug history would influence subsequent drug preference in distinct settings. Based on a theoretical model of drug-setting interaction, we predicted that regardless of drug history rats would prefer heroin at home and cocaine outside the home.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1273552
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