Many findings support the role of β human papillomaviruses (HPVs) in cutaneous squamous cell carcinoma (cSCC) and its precursor Actinic Keratosis (AK), in cooperation with UV radiation. Differently from the mucosal high-risk types, which are required throughout the entire carcinogenic process, β-HPVs appear to play a role only at an early stage of skin carcinogenesis. Indeed, β-HPV DNA is not present in all cancer cells and cutaneous HPV prevalence and/or viral load is higher in AK than in cSCC.
Comprehensive analysis of β and γ human papillomaviruses in actinic keratosis and apparently healthy skin of elderly patients / Donà, M. G.; Chiantore, M. V.; Gheit, T.; Fiorucci, G.; Vescio, M. F.; La Rosa, G.; Accardi, L.; Costanzo, G.; Giuliani, M.; Romeo, G.; Rezza, G.; Tommasino, M.; Luzi, F.; Di Bonito, P.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - (2019). [10.1111/bjd.17836]
Comprehensive analysis of β and γ human papillomaviruses in actinic keratosis and apparently healthy skin of elderly patients
Romeo, G.;
2019
Abstract
Many findings support the role of β human papillomaviruses (HPVs) in cutaneous squamous cell carcinoma (cSCC) and its precursor Actinic Keratosis (AK), in cooperation with UV radiation. Differently from the mucosal high-risk types, which are required throughout the entire carcinogenic process, β-HPVs appear to play a role only at an early stage of skin carcinogenesis. Indeed, β-HPV DNA is not present in all cancer cells and cutaneous HPV prevalence and/or viral load is higher in AK than in cSCC.| File | Dimensione | Formato | |
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