No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities. Considering the variability in HIV-RNA quantification assays, the biological relevance of viral escape at different thresholds needs to be accurately assessed.
Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities. Is it time to assess the definitions? / Trunfio, M., Pinnetti, C., Focà, E., Bai, F., Maffongelli, G., Celani, L., Cinque, P., Celotti, A., Andreoni, M., D'Arminio Monforte, A., D'Ettorre, G., Antinori, A., Calcagno, A.. - In: AIDS. - ISSN 1473-5571. - 33:4(2019), pp. 759-762. [10.1097/QAD.0000000000002091]
Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities. Is it time to assess the definitions?
Maffongelli, Gaetano;Celani, Luigi;Andreoni, Massimo;D'Arminio Monforte, Antonella;D'Ettorre, Gabriella;
2019
Abstract
No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities. Considering the variability in HIV-RNA quantification assays, the biological relevance of viral escape at different thresholds needs to be accurately assessed.| File | Dimensione | Formato | |
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